| 雪芙蓉胶囊对大负荷训练大鼠运动能力及大脑伏隔核c-fos表达的影响 |
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| 引用本文： | 崔建梅,药宏亮,刘鸿宇,薛金娟.雪芙蓉胶囊对大负荷训练大鼠运动能力及大脑伏隔核c-fos表达的影响[J].北京体育大学学报,2012(7):52-57. |
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| 作者姓名： | 崔建梅 药宏亮 刘鸿宇 薛金娟 |
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| 作者单位： | 中北大学运动医学研究所 |
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| 基金项目： | 中北大学青年基金资助“去势雄性大鼠下丘脑、海马及杏仁体c-fos、DA、Nos的变化和补肾中药增强体能的作用”(2009-2011) |
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| 摘 要： | 目的:观察中药雪芙蓉胶囊对雄性大鼠力竭跑台时间、血清雄激素及乳酸水平、血浆pH值及大脑伏隔核c-fos表达的影响。方法:将30只雄性成年大鼠随机分为3组,即安静对照组、训练组、中药训练组。中药训练组每天灌服雪芙蓉胶囊(5 mg/kg),8周后测试大鼠力竭跑台时间,检测血清睾酮、乳酸含量及血浆pH值,用免疫组织化学方法结合图像半定量方法对c-fos神经元的数量、面积及灰度进行测量和分析。结果:与训练组比较,中药训练组大鼠力竭跑台时间延长、血清睾酮及血浆pH增高(P<0.01,P<0.05,P<0.05)、血清乳酸下降(P<0.05);伏隔核c-fos免疫阳性细胞数量和阳性产物面积表达均降低(P<0.05),灰度没有显著差异(P>0.05)。结论:中药雪芙蓉胶囊可提高大鼠的运动能力,延缓中枢疲劳,机理可能与此中药提高力竭运动大鼠血清睾酮水平及血浆pH值,同时降低大鼠血清乳酸水平及大脑伏隔核c-fos的过度表达有关。
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| 关 键 词： | 雪芙蓉胶囊 运动能力 雄激素 乳酸 伏隔核 c-fos |
Effects of Xuefurong Capsule on the Sports Ability and c-fos Expression within Nac in Overload Training Rats |
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| CUI Jian-mei,YAO Hong-liang,LIU Hong-yu,XUE Jin-juan.Effects of Xuefurong Capsule on the Sports Ability and c-fos Expression within Nac in Overload Training Rats[J].Journal of Beijing Sport University,2012(7):52-57. |
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| Authors: | CUI Jian-mei YAO Hong-liang LIU Hong-yu XUE Jin-juan |
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| Institution: | (Institute of Sports Medicine,North University of China,Taiyuan 030051,Shanxi China) |
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| Abstract: | Objective:To explore the effects of Xuefurong capsule on the time of exhausted treadmill,the level of serum testosterone,lactic acid(LA),the PH of blood plasma,and expression of c-fos within nucleus accumbens(Nac) of brain in the male rats.Method: 30 SD rats were randomly divided into 3 groups: the sedentary control group,the training group,and the Chinese-medicine and training group.The Chinese-medicine and training group were forced to take Xuefurong capsule every day(5mg/kg) and lasted 8 weeks.Then the time of exhausted treadmill of rats was tested,the level of serum testosterone,the LA and the PH of blood plasma were examined,c-fos expression within Nac was detected and analysised by using ABC immunohistochemical technique and semi quantitative.Result: Compared with the training group,the time of exhausted treadmill was prolonged(P<0.01),the level of testosterone and PH of blood plasma increased(P<0.05,P<0.05),the level of LA decreased(P<0.05);The amount and area of c-fos within Nac obviously decreased(P<0.05),the gray degree was not significant different(P>0.05) in the Chinese medicine and training group.Conclusion: Taking Xuefurong capsules may enhance the sports ability,its mechanism might be that Xuefurong capsule increase the level of serum testosterone and PH blood of plasma,decrease the level of serum LA and excessive expression of c-fos within Nac at the same time. |
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| Keywords: | Xuefurong capsule sports ability testosterone lactic acid nucleus accumbens c-fos |
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