| 甘草黄酮对大强度耐力运动大鼠肾脏组织细胞凋亡及Bax、Bcl-2蛋白表达的影响 |
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| 引用本文： | 陈艳艳.甘草黄酮对大强度耐力运动大鼠肾脏组织细胞凋亡及Bax、Bcl-2蛋白表达的影响[J].北京体育大学学报,2011,34(2):61-64. |
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| 作者姓名： | 陈艳艳 |
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| 作者单位： | 西北大学体育部; |
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| 基金项目： | 陕西省自然科学基金资助项目(SJ08F22) |
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| 摘 要： | 目的:探讨甘草黄酮对大强度耐力运动大鼠肾脏组织细胞凋亡及Bax(促凋亡基因,B apoptosis cell matrixgene)、Bcl-2(B细胞淋巴瘤基因-2,B cell lymphoma gene-2)蛋白表达的影响。方法选取SD雄性健康大鼠24只,随机分为安静组、大强度运动组和运动加药组;采用跑台训练6周后取材,应用免疫组织化学法测检测各组大鼠肾脏组织细胞凋亡及Bax和Bcl-2蛋白表达的变化。结果:与安静对照组相比,大强度耐力运动组和运动加药组大鼠细胞凋亡指数AI均有不同程度增加;大强度运动组Bax、Bcl-2蛋白表达(MOD)均呈非常显著差异性(P<0.01),运动加药组Bax蛋白表达(MOD)均呈非常显著差异性(P<0.01);运动加药组Bcl-2蛋白表达(MOD)与大强度运动组具有非常显著差异性(P<0.01);大强度运动组和运动加药组Bax/Bcl-2比值分布呈不同程度的显著差异性(P<0.05,P<0.01)。结论:甘草黄酮能够提高大强度运动大鼠抗氧化能力,降低肾脏组织自由基的产生,抑制肾脏组织细胞的凋亡。
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| 关 键 词： | 甘草黄酮 大强度耐力训练 肾脏 细胞凋亡 Bax Bcl-2 |
Effect of High-intensity Endurance Exercise on Apoptosis and Bax,Bcl-2 Protein Expression with Glycyrrhiza Flavonoids in Rat Nephridial Tissue |
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| CHEN Yan-yan.Effect of High-intensity Endurance Exercise on Apoptosis and Bax,Bcl-2 Protein Expression with Glycyrrhiza Flavonoids in Rat Nephridial Tissue[J].Journal of Beijing Sport University,2011,34(2):61-64. |
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| Authors: | CHEN Yan-yan |
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| Institution: | CHEN Yan-yan(P.E.Department,Northwest University,Xi′ an 710069,Shaanxi China) |
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| Abstract: | Objective: To explore glycyrrhiza flavonoids on the rat nephridial tissue of cell apoptosis and Bax,Bcl-2 protein expression with high-intensity endurance exercise.Methods: The twenty-four healthy male rats were randomly divided into control group,high-intensity exercise group and exercise plus glycyrrhiza flavonoids group.After 6 weeks of treadmill training,by using the box of reagent and immunity histochemistry,the research examined the change of cell apoptosis and Bax,Bcl-2 protein expression on each gro... |
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| Keywords: | glycyrrhiza flavonoids high-intensity exercise nephridial tissue cell apoptosis Bax Bcl-2 |
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