| 补充精氨酸对过度训练大鼠肌糖原、AMPK 及GLUT- 4 的影响 |
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| 引用本文： | 刘无逸,陆爱云.补充精氨酸对过度训练大鼠肌糖原、AMPK 及GLUT- 4 的影响[J].天津体育学院学报,2010,25(4):340-343. |
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| 作者姓名： | 刘无逸 陆爱云 |
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| 作者单位： | 上海体育学院运动科学学院,上海,200438 |
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| 基金项目： | 上海市教委课题，上海市重点学科建设项目 |
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| 摘 要： | 目的：观察体外补充L－精氨酸对过度训练大鼠的作用。方法：9 周龄SD 雌性大鼠40 只，随机分为安静对照组（A 组）、大强度运动组（B
组）、大强度运动服L- 精氨酸组（C 组）、过度训练组（D 组），其中D1 组为过度训练组，D2 组为过度训练加服L- 精氨酸组。上坡跑训练9 周后测各组白腓肠肌和比目鱼肌的肌糖原含量、AMPK 活性和肌膜GLUT- 4 含量。结果：B 组和D1 组糖原含量较A 组有升高趋势，但无显著性；C 组显
著高于A 组（P<0.01）；D2 组大鼠比目鱼肌糖原含量较A 组显著升高（P<0.01）；D2 组较D1 组升高，但未达到显著水平（P>0.05）。B 组、C 组和D2组AMPK 活性显著高于A 组（P<0.01）；D2 组较D1 组有明显增加，差异显著（P<0.05）。B 组、C 组和D2 组GLUT- 4 含量分别较A 组增加100%左右，D1 组增加11%；D2 组较D1 组增加57%。结论：体外补充L- 精氨酸可能有利于延缓或治疗过度训练。
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| 关 键 词： | 大鼠 过度训练 L-精氨酸 肌糖原 AMP-活化的蛋白激酶 葡萄糖载体蛋白-4 |
Effect of Supplying L-arginine on Skeletal Muscle Glycogen, AMPK Activity and Sarcolemma GLUT4 Protein
Contents in Overtraining Rats |
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| LIU Wuyi,LU Aiyun.Effect of Supplying L-arginine on Skeletal Muscle Glycogen, AMPK Activity and Sarcolemma GLUT4 Protein
Contents in Overtraining Rats[J].Journal of Tianjin Institute of Physical Education,2010,25(4):340-343. |
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| Authors: | LIU Wuyi LU Aiyun |
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| Institution: | School of Sport & Exercise Science, Shanghai University of Sport, Shanghai 200438, China |
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| Abstract: | Objective: The purpose of the present study was to observe effect of supplying L-arginine on skeletal muscle glycogen contents, AMP-activated protein kinase (AMPK) activity and sarcolemma Glucose transporter type 4 (GLUT4) protein contents in overtraining rats. Methods: Forty SD rats were randomly divided into group A (sedentary), group B (underwent endurance exercise 60 minutes/day), group C (underwent endurance exercise 60 minutes/day,supplying L-arginine) and group D (underwent endurance exercise 120 minutes/day), group D subdivided group D1 (without L-arginine) and group D2 (with L-arginine). All exercise groups were trained 6 days/wk for 9 weeks. Muscle glycogen, sarcolemma GLUT4 contents and muscle AMPK activity were determined after the 9-week training. Results: Muscle glycogen contents in group B and group D1 exist a trend of increase compared with that in group A, but not significantly (P>0.05). Muscle glycogen contents in soleus showed a significant higher level in group C and group D2 compared with that in group A (P<0.01),and it showed a trend of increase in group D2 compared with that in group D1, but not significantly (P>0.05). Muscle AMPK activity in group B, group C and
group D2 increased significantly compared with that in group A, and it showed a significant higher level in group D2 compared with that in group D1( P<0.01).Sarcolemma GLUT4 contents in group B, group C and group D2 increased about 100% compared with that in group A, but it only increased 11% in group D1.And that increased by 57% in group D2 as compared with that in group D1. Conclusion: Supplying with L-Arg could increase muscle glycogen cotents,muscle AMPK activity, and sarcolemma GLUT4 content in overtraining rats, which might be helpful in staying or treating overtraining. |
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| Keywords: | rat overtraining L-arginine muscle glycogen GLUT4 AMPK |
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