| 不同运动负荷大鼠心脏血流动力学变化对左心室内皮细胞形态影响的实验研究 |
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| 引用本文： | 田振军.不同运动负荷大鼠心脏血流动力学变化对左心室内皮细胞形态影响的实验研究[J].天津体育学院学报,1999,14(1):46-48. |
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| 作者姓名： | 田振军 |
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| 作者单位： | 陕西师范大学体育学院暨运动生物学研究所 |
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| 摘 要： | 采用Ｓ－５７０型扫描电镜和ＲＭ－６２００多道生理记录仪观察分析了大鼠不同运动条件下的心脏血流动力学参数及左心室几何构型和内皮细胞形态变化。结果表明，一般运动负荷导致心脏发生生理性肥大，左心室血流动力学指标升高，左心室流出道内皮细胞由于壁面切应力作用呈流畅梭形，其排列方向与血流方向一致，左心室心尖部由于涡流及二次流作用，内皮细胞呈现卵石样外观，形态各异，排列无序；运动超负荷导致心脏肥大的同时左心室血流动力学指标降低，心脏发生缺血缺氧性损伤，左心室流出道内皮细胞过度拉伸，个别内皮细胞损伤，左心室心尖部内皮细胞损伤严重，红细胞及血小板粘附。提示运动超负荷左心室内皮细胞损伤的病理生理机制主要是由左室壁面切应力、涡流和血液淤滞及心内膜下缺血缺氧共同作用的结果
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| 关 键 词： | 运动负荷 大鼠 血流动力学 内皮细胞 扫描电子显微镜 |
EXPERIMENTAL STUDY OF EFFECTS OF HEMODYNAMIC ALTERATIONS ON LEFT VENTRICLE ENDOTHELIAL CELL MORPHOLOGY IN RATS UNDER DIFFERENT EXERCISE LOADS |
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| TIAN Zhen-jun.EXPERIMENTAL STUDY OF EFFECTS OF HEMODYNAMIC ALTERATIONS ON LEFT VENTRICLE ENDOTHELIAL CELL MORPHOLOGY IN RATS UNDER DIFFERENT EXERCISE LOADS[J].Journal of Tianjin Institute of Physical Education,1999,14(1):46-48. |
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| Authors: | TIAN Zhen-jun |
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| Institution: | TIAN Zhen jun |
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| Abstract: | The present study analyses hemodynamic parameters and left ventricle(LV) geometric configuration and endothelial cell(EC) morphology using S-570 scanning electron-microscopy and RM-6200 polygraph under different exercise loads.Results show that general load exercise can lead to physiological cardiac hypertrophy,elevation of LV hemodynamic indicators,shuttle-shaped LV efferent tract ECs arranging consistent with blood flow direction and pebble-shaped LV apex ECs with disorder arrangement.Results also show that overload exercise can lead to pathological cardiac hypertrophy,decrease in LV hemodynamic indicators,ischemic and anoxic cardiac injury,overextention and injury of LV efferent tract ECs,serious injury of LV apex ECs and adherence of red blood cell and platelet.The paper indicates that pathophysiological mechanisms of injury of LV ECs are the tangent stress,vortex flow,hypostasis,ischemic and anoxic subendocardial in the LV wall after overload exercise. |
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| Keywords: | exercise load rat hemodynamics endothelial cell(EC) scanning electron-microscopy |
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