| 急性运动心肌缺氧对大鼠心肌纤维和线粒体膜结构及功能的影响?? |
| |
| 引用本文： | 张 勇??,张 薇,时庆德,李静先,陈家琦.急性运动心肌缺氧对大鼠心肌纤维和线粒体膜结构及功能的影响??[J].天津体育学院学报,1997,12(1):18-22. |
| |
| 作者姓名： | 张 勇?? 张 薇 时庆德 李静先 陈家琦 |
| |
| 作者单位： | 天津体育学院运动医学研究所 |
| |
| 基金项目： | 天津市高教局管理课题( 部分工作) |
| |
| 摘 要： | 采用递增负荷耗竭运动模型为急性缺氧应激源，观察了ＳＤ大鼠急性运动至力竭后心肌组织和线粒体膜过氧化脂质含量，线粒体内膜ＮＡＤＨ－ＣｏＱ还原酶活性变化和心肌纤维和线粒体超微结构。结果表明，心肌能量需求过高性缺氧应激后大鼠心肌组织匀浆和线粒体膜过氧化脂含量分别增高１４０．９％和３９．４％（Ｐ＜０．０１和Ｐ＜０．０５），线粒体内膜ＮＡＤＨ－ＣｏＱ还原酶活性降低６１．６％（Ｐ＜０．０５），心肌纤维和线粒体超微结构呈缺氧损伤性改变。研究提示，急性运动缺氧应激后心肌组织和心肌线粒体膜结构变化与脂质过氧化作用增强有关
|
| 关 键 词： | 耗竭运动 心肌缺氧 线粒体膜 过氧化脂质 NADH－CoQ还原酶 |
| 收稿时间： | 5/7/1996 12:00:00 AM |
EFFECTS OF ACUTE EXERCISE-INDUCED HYPOXIA ON MYOCARDIAL FIBERS AND STRUCTURE AND FUNCTION OF MYOCARDIAL MITOCHONDRIAL MEMBRANE IN RAT |
| |
| Zhang Yong,Zhang Wei,Shi Qingde,Li Jingxian and Chen Jiaqi.EFFECTS OF ACUTE EXERCISE-INDUCED HYPOXIA ON MYOCARDIAL FIBERS AND STRUCTURE AND FUNCTION OF MYOCARDIAL MITOCHONDRIAL MEMBRANE IN RAT[J].Journal of Tianjin Institute of Physical Education,1997,12(1):18-22. |
| |
| Authors: | Zhang Yong Zhang Wei Shi Qingde Li Jingxian and Chen Jiaqi |
| |
| Institution: | Zhang Yong Zhang Wei Shi Qingde Li Jingxian Chen Jiaqi |
| |
| Abstract: | The present study investigates lipid peroxide contents of myocardial tissue and mitochondrial membrane, the NADH CoQ reductase activity of inner mitochondrial membrane and the ultrastructure of myocardial fibers and mitochondria in SD rat after acute exercises to exhaustion adopting an incremental exhaustied exercise model as acute hypoxia stress source. Results show that lipid peroxide contents of myocardium and myocardial mitochondrial membrane increase by 140.9% and 39.4% respectively (P<0.01 and P<0.05), the NADH CoQ reductase activity of inner mitochondrial membrane decreases by 61.1% (P<0.05) and ultrastructures of myocardial fibers and mitochondria present hypoxic pathological changes in rat with high energy demand myocardium after the hypoxia stress. The research suggests that the lipid peroxidation may be responsible for structural changes of myocardium and myocardial mitochondrial membrane during acute exercise induced hypoxia stress. |
| |
| Keywords: | exhaustied exercises myocardium hypoxia mitochondrial membrane lipid peroxides NADH CoQ reductase |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《天津体育学院学报》浏览原始摘要信息 |
| 点击此处可从《天津体育学院学报》下载免费的PDF全文 |
