| 电刺激前脑内侧束对运动疲劳大鼠纹状体神经元诱发电活动的影响 |
| |
| 引用本文： | 刘晓莉,吴迪,乔德才,侯莉娟.电刺激前脑内侧束对运动疲劳大鼠纹状体神经元诱发电活动的影响[J].西安体育学院学报,2012,29(1):72-77. |
| |
| 作者姓名： | 刘晓莉 吴迪 乔德才 侯莉娟 |
| |
| 作者单位： | 北京师范大学体育与运动学院,北京,100875 |
| |
| 基金项目： | 国家自然科学基金资助项目 |
| |
| 摘 要： | 目的通过电刺激前脑内侧束(medial forebrain bundle,MFB),观察运动疲劳大鼠纹状体(striatum,STR)神经元诱发放电变化特征,揭示黑质(substantia nigra,SN)-STR多巴胺(dipamine,DA)能神经通路对运动疲劳调控的机制。方法雄性健康SD大鼠32只,随机分为安静对照组(control group,CG)和运动疲劳组(fatigue group,FG),每组16只,建立递增负荷运动疲劳模型。电刺激大鼠MFB并微量注射多巴胺Ⅰ型受体(D1 dopamine receptor,D1DR)拮抗剂氟哌啶醇(HAL),采用玻璃微电极观察运动疲劳对SN-STR神经通路电活动的影响。结果运动疲劳后,诱发大鼠STR神经元产生最大兴奋性反应的刺激频率较CG明显增大(P<0.05),抑制性反应单位比例增多,HAL对抑制性反应单位有敏感的阻断作用。结论运动疲劳后,STR诱发放电的频率达到最大值的刺激阈强度增加,SNc区的DA能神经系统主要通过D2DR的作用对STR的电活动进行调节,提示SN-STR DA能神经通路参与了运动疲劳的中枢调控作用。
|
| 关 键 词： | 电刺激 前脑内侧束 运动性疲劳 纹状体 电活动 |
Impact of Electrical Stimulating MFB on Neuron Electric Activity of STR in Exercise - Induced Fatigue Rat |
| |
| LIU Xiao-li
,
WU Di
,
QIAO De-cai
,
HOU Li-juan.Impact of Electrical Stimulating MFB on Neuron Electric Activity of STR in Exercise - Induced Fatigue Rat[J].Journal of Xi'an Institute of Physical Education,2012,29(1):72-77. |
| |
| Authors: | LIU Xiao-li WU Di QIAO De-cai HOU Li-juan |
| |
| Institution: | (College of PE and Sports,Beijing Normal University,Beijing 100875,China) |
| |
| Abstract: | Objective The changes of STR neuron electric activity through stimulating median forebrain bundle（MFB） to reveal the regulatory role and mechanism of substantia nigra-striatum DA nerve pathway for exercise-induced fatigue.Methods: 32 healthy and males SD rats were used,randomly dividing into control group（CG） which was not trained and fatigue group（FG） which was trained for fatigue.16 of them are in each group.The incremental exercise fatigue model was established.Electroneurophysiology extracellular record method was used to observe the changes of STR neuron electric activity through stimulating MFB and Micro-injecting DA receptor 1 antagonists（D1DR）（HAL）.Results The ratio of MFB-STR inhibitory reaction increased after fatigue（P<0.05）.HAL could intercept MFB-STR inhibitory sensitively;The frequency of MFB-STR excitability reaction was accrescenced as the increasing of stimulus intensity（P<0.05）.Conclusion Micro-injecting HAL can flip-flop the MFB-STR unit from inhibitory to excitability after exercise-induced fatigue,the SNc dopaminergic nervous system adjust the STR electric activity mainly through D2DR;There are different reaction domains to SNc in STR. |
| |
| Keywords: | electrical stimulation medial forebrain bundle exercise-induced fatigue striatum electric activity |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
