| 运动调节骨骼肌线粒体质量控制的研究进展 |
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| 引用本文： | 张,庆.运动调节骨骼肌线粒体质量控制的研究进展[J].体育科研,2020(4):52-59. |
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| 作者姓名： | 张 庆 |
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| 作者单位： | 苏州大学 体育学院，江苏 苏州 215021 。 |
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| 基金项目： | 江苏省高等学校自然科学研究面上项目（18KJB180025）；苏州市科学技术局科技计划项目（SYS201711）。 |
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| 摘 要： | 线粒体生物发生、线粒体融合-分裂和线粒体自噬之间的平衡对线粒体质量控制、维持细胞功能和骨骼肌能量稳态至关重要。骨骼肌线粒体功能障碍与许多疾病的发生密切相关，包括与衰老相关的肌肉减少症、肌萎缩、肌营养不良和II型糖尿病等。本文聚焦骨骼肌线粒体生物发生和功能的精细调节网络，综述了运动对骨骼肌线粒体质量控制的调节作用，为未来相关领域的研究提供理论基础并作出展望。
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| 关 键 词： | 线粒体质量控制 线粒体自噬 线粒体生物发生 骨骼肌 运动 |
Research Progress of Exercise Regulated Skeletal Muscle Mitochondrial Quality Control |
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| ZHANG Qing.Research Progress of Exercise Regulated Skeletal Muscle Mitochondrial Quality Control[J].Sports Science Research,2020(4):52-59. |
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| Authors: | ZHANG Qing |
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| Institution: | College of Physical Education and Sports, Soochow University, Suzhou 215021 , China |
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| Abstract: | The balance among mitochondrial biogenesis, mitochondrial fusion/fission and mitochondrial autophagy are very important for mitochondrial quality control, cell function and skeletal muscle energy homeostasis. Mitochondrial dysfunction of skeletal muscle is closely related to many diseases, including aging-related sarcopenia, muscular atrophy, muscular dystrophy and type 2 diabetes mellitus. This paper focuses on the fine regulatory network of mitochondrial biogenesis and function in skeletal muscle, reviews the research progress of the regulation of exercise on the quality control of skeletal muscle mitochondria, so as to provide a theoretical basis for future researches in the related fields. |
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