| 肌腱疲劳性损伤与胶原合成 |
| |
| 引用本文： | 张 林,李 敏.肌腱疲劳性损伤与胶原合成[J].体育科研,2013,34(2):28-31. |
| |
| 作者姓名： | 张 林 李 敏 |
| |
| 作者单位： | 1. 苏州大学体育学院,江苏苏州,215021
2. 商丘师范学院体育学院,河南商丘,476000 |
| |
| 摘 要： | 腱病主要是因为过度使用所导致的疲劳性损伤，明确重复负载下肌腱中分子反应不仅有利于理解腱病发展，而且有利于发现新的预防、治疗和康复措施。本文综述了运动后和疲劳负载下，肌腱中胶原的合成和生长因子的作用，以探讨肌腱疲劳性损伤早期的分子机制、资料研究表明，不同运动和疲劳负载下肌睫中胶原亚型表达不同，并具有载荷剂量依赖性；在这些机械刺激下一些生长因子如生长因子（TGFβ-1）、胰岛素生长因子（IGF-Ⅰ）、白介素-6（IL-6）等可能起到重要的调节作用。
|
| 关 键 词： | 肌腱 疲劳性损伤 胶原 |
Tendon fatigue damage and collagen synthesis |
| |
| ZHANG,Lin and LI Min.Tendon fatigue damage and collagen synthesis[J].Sports Science Research,2013,34(2):28-31. |
| |
| Authors: | ZHANG Lin and LI Min |
| |
| Institution: | School of Physical Education, Soochow University |
| |
| Abstract: | Tendinopathy is caused by overuse which results in fatigue damage. The paper makes it clear that molecule response of tendon under repeated load will not only help understand the progress of tendinopathy, but also help find the new measures for prevention, treatment and rehabilitation. The paper elaborates on the tendon collagen synthesis and the function of growth factors after exercise and under fatigue load in order to investigate the early molecular mechanism of tendon fatigue damage. Diverse responses of collagen subtypes, as well as the dose-dependency of load, are observed after different exercise and under different fatigue load. In response to mechanical stimulation, some growth factors such as TGF β -1, IGF-Ⅰ and IL-6 may play a vital role of regulation. |
| |
| Keywords: | tendon fatigue damage collagen |
| 本文献已被 维普 万方数据 等数据库收录！ |
| 点击此处可从《体育科研》浏览原始摘要信息 |
| 点击此处可从《体育科研》下载免费的PDF全文 |
|
