| 大蒜素对一次大强度运动后心肌肌钙蛋白及抗氧化能力的影响 |
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| 引用本文： | 李建钢,蔡文丽.大蒜素对一次大强度运动后心肌肌钙蛋白及抗氧化能力的影响[J].武汉体育学院学报,2012,46(4):89-92. |
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| 作者姓名： | 李建钢 蔡文丽 |
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| 作者单位： | 河南大学体育学院,河南开封,475001 |
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| 基金项目： | 河南省科技厅科技攻关项目，河南省教育厅自然科学基金 |
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| 摘 要： | 目的:观察大蒜素对一次大强度运动后大鼠cTn-I、cTn-T、T-AOC和MDA等的影响.方法:8周龄SPF级SD雄性大鼠100只,随机分为空白对照组(C组,n=10)、大蒜素对照组(CA组,n=10)、运动组(E组,n=40)和大蒜素运动组(EA组,n=40).C、E组腹腔注射等剂量生理盐水;CA、EA组腹腔注射大蒜素注射液,4周后,E组、EA组进行一次性大负荷跑台运动,按时相取股动脉血分离血清检测cTn-I、cTn-T、T-AOC和MDA.结果:血清cTn-I含量,E组和EA组各时相均非常显著性高于对照组;EA组和E比较,运动后各时相均较低,其中运动后6h、24 h差异具有显著性;血清cTn-T含量,E组和EA组运动后均低于对照组,其中E组运动后各时相差异均非常显著,EA组运动后6h、12 h 、24 h差异具有非常显著性,运动后即刻具有显著性差异;组间同时相比较,EA组运动后即刻和24 h显著性、运动后12h非常显著性低于E组.血清T-AOC,CA组显著性高于C组,EA组运动后即刻、24 h显著性高于E组同时相.血清MDA含量,运动后E组、EA组均升高,EA组各时相均低于E组,其中运动后12h差异具有显著性,运动后24 h差异具有非常显著性.结论:大强度跑台运动可诱发大鼠运动性心肌损伤.大蒜素可提高抗氧化能力,减轻大鼠大强度运动后心肌细胞损伤,减少cTn-I、cTn-T的大量逸出,对保护细胞膜完整性,降低运动应激程度,防治运动性心肌微损伤有积极作用.
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| 关 键 词： | 运动损伤 大蒜素 大强度运动 cTn-I cTn-T T-AOC MDA |
Impact of Intervention of Allicin on Myocardial Troponin and Antioxidant Capacity in Rats after High Intensity Exercise |
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| LI Jiangang
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CAI Wenli.Impact of Intervention of Allicin on Myocardial Troponin and Antioxidant Capacity in Rats after High Intensity Exercise[J].Journal of Wuhan Institute of Physical Education,2012,46(4):89-92. |
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| Authors: | LI Jiangang CAI Wenli |
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| Institution: | (Inst.of P.E.,Henan Univ.,Kaifeng 475001,China) |
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| Abstract: | The purpose of this research was to observe the effects of garlicin on a high intensity exercise in rats after cTn-I,cTn-T,T-AOC and MDA effect.One hundred eight-week-old SPF SD male rats were randomly divided in to control group(Group C,n=10),and the control group(Group CA,n=10),the exercise group(Group E,n=40)and Allicin exercise group(Group EA,n=40).GroupC and Group E were injected intraperitoneally and dose of normal saline.Group CA and Group EA took intraperitoneal injection of garlicin injection.In four weeks,Group E and group EA were given a big load treadmill exercise,unilateral femoral artery blood serum separation detection of cTn-I,cTn-T,T-AOC and MDA were taken according to the corresponding phases.It showed that the content of serum cTn-I of Group E and Group EA group in each phase were significantly higher than those in control group(P < 0.01).Those of Group EA and Group E were relatively low while six hours after exercise the figures were signif icantly differnt(P < 0.05),24 h(P < 0.01).The content of cTn-T in Group E and Group EA after exercise were lower than that of the control group.Big differences were seen in Group E(P < 0.01)and in Group EA six hours,twelve hours and twenty four hours after exercise(P < 0.01),Obvious differences were seen immediately after exer cise(P < 0.05).Serum T-AOC of Group CA was significant higher than that in Group C(P < 0.05)and Group EA(P < 0.05).The content of serum MDA increased in Group E and Group EA with that of Gruop E higher.There was |
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| Keywords: | sports injury allicin high intensity exercise cTn-I cTn-T T-AOC MDA |
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