Aerobic fitness and physical activity are inversely associated with body fat,dyslipidemia and inflammatory mediators in children and adolescents living with HIV |
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| Authors: | Luiz Rodrigo Augustemak de Lima Isabela de Carlos Back Everson Araújo Nunes Diego Augusto Santos Silva Edio Luiz Petroski |
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| Institution: | 1. Department of Physical Education, Research Centre for Kinanthropometry and Human Performance, Federal University of Santa Catarina, Florianópolis, Brazil;2. Department of Pediatrics, Medical School, Federal University of Santa Catarina, Florianópolis, Brazil;3. Physiological Sciences Department, Centre of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil |
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| Abstract: | This study aimed to investigate if moderate to vigorous physical activity (MVPA) and aerobic fitness are associated with cardiovascular risk factors in HIV+ children and adolescents. Sixty-five children and adolescents (8 to 15 years) provided minutes of MVPA measured by accelerometers and peak oxygen uptake (peak VO2) by breath-by-breath respiratory exchange. Cardiovascular risk factors were characterized by body fat, blood pressure, total cholesterol, HDL-c, LDL-c, triglycerides, glucose, insulin, C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α) and carotid intima-media thickness. Results indicated that higher MVPA was associated with lower values of total (β = ?3.566) and trunk body fat (β = ?3.495), total cholesterol (β = ?0.112) and LDL-c (β = ?0.830). Likewise, higher peak VO2 was associated with lower total (β = ?0.629) and trunk body fat values (β = ?0.592) and levels of CRP (β = ?0.059). The physically active participants had lower total cholesterol (?24.4 mg.dL?1) and LDL-c (?20.1 mg.dL?1) compared to participants judged to be insufficiently active. Moreover, participants with satisfactory peak VO? showed lower total (?4.1%) and trunk (?4.3%) body fat, CRP (?2.3 mg.L?1), IL-6 (?2.4 pg.mL?1) and TNF-α (?1.0 pg.mL?1) compared to low peak VO2 peers. High levels of MVPA and aerobic fitness may prevent developing of cardiovascular risk factors in children and adolescents HIV+. |
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| Keywords: | Cardiorespiratory fitness atherosclerosis inflammation dyslipidemias AIDS |
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