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| 中国北方汉族男子FECH基因-252A/G多态与耐力训练敏感性的关联研究 | |
| 引用本文： | 许亚丽,胡扬,李厚林,席翼,文力,何子红.中国北方汉族男子FECH基因-252A/G多态与耐力训练敏感性的关联研究[J].沈阳体育学院学报,2012,31(3):1-4. |
| 作者姓名： | 许亚丽 胡扬 李厚林 席翼 文力 何子红 |
| 作者单位： | 1. 河南大学体育学院,河南开封,475000 2. 北京体育大学体育科学研究中心,北京,100084 3. 西安体育学院田径教研室,陕西西安,710068 4. 深圳大学体育系,广东深圳,518060 5. 天津体育学院运动人体科学系,天津,300381 6. 国家体育总局体育科学研究所,北京,100763 |
| 摘 要： | 目的:探讨中国北方汉族男性亚铁螯合酶(FECH)基因-252A/G多态性与耐力训练敏感性的关联,寻找与有氧耐力训练效果的分子标记。方法:选取102名中国北方汉族男性健康受试者,以95%～105%个体无氧阈强度进行5 000米跑训练,每周3次,共18周,训练前后测定VO2max、RE等指标。使用PCR-RFLP和测序方法解析该基因多态性的分布特征,并进行该多态与上述生理指标进行关联性分析。结果:1)耐力训练前,AA基因型跑节省化时的心率(RE/HR)、跑节省化时的最大摄氧量(RE/rVO2)起始值均显著性低于GG基因型(P<0.01);2)有氧耐力训练后,AA基因型通气阈时的摄氧量(△VT/VO2)增加的幅度显著性高于GG基因型(P<0.05);AA基因型在跑节省化时的心率(△RE/HR)下降的幅度显著性高于GG基因型(P<0.05)。结论:在FECH基因-252A/G多态性中,AA基因型耐力训练具有较高的训练敏感性,可作为预测有氧耐力训练敏感性的分子标记。 |
| 关 键 词： | 亚铁螯合酶 基因多态性 有氧运动能力 |
Association between -252A/G Polymorphism of FECH Gene and Endurance Training Response in Men of HAN Nationality in Northern China |
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| XU Yali , HU Yang , LI Houlin , XI Yi , WEN Li , HE Zihong.Association between -252A/G Polymorphism of FECH Gene and Endurance Training Response in Men of HAN Nationality in Northern China[J].Journal of Shenyang Sport University,2012,31(3):1-4. | |
| Authors: | XU Yali HU Yang LI Houlin XI Yi WEN Li HE Zihong |
| Institution: | 1.Physical Education College of Henan University,Kaifeng,475000,Henan,China; 2.Research Center of Sports Science,Beijing Sport University,Beijing 100084,China; 3.Faculty of Track and Field,Xi’an Physical Education University,Xi’an 710068,Shaanxi,China; 4.Physical Education Department,Shenzhen Universeity,Shenzhen 518060,Guangdong,China; 5.Department of Human Sports Science,Tianjin Institute of Physical Education,Tianjin 300381,China; 6.Institute of Sports Science,General Administration of Sport of China,Beijing 100763,China) |
| Abstract: | Introduction:To investigate the association betweem-252A/G polymorphism of FECH Gene and aerobic ability in men of Han nationality in Northern China.Methods:102 healthy young male soldiers of Han Nationality in Northern China were recruited to undergo 18-week 5000m running 3 times a week.The VO2max、 RE were measured before and after protocol.GeneScan and gene sequencing was used to analyse the-252A/G polymorphism.The association of the polymorphism with initial endurance capacity and endurance training response was analysed.Result:1)Before endurance training,the running economy baseline(RE/HR、 RE/rVO2) in AA genetype was significantly lowerer than in GG genetype(P<0.01);2)After endurance training,the changing rate of VO2(△VT/VO2)in AA genetype was significantly higher than in GG genetype(P<0.05),the changing rate of running economy(△RE/HR)in AA genetype was significantly lower than in GG genetype(P<0.05).Conclusion:The AA genetype of-252A/G polymorphism inFECH Gene has association not only with initial aerobic capacity but also with the sensibility to endurance training,so it could be the genetic marker in predicting endurance training response. |
| Keywords: | ferrochelatase gene polymorphism endurance training |
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