| 有氧运动对糖尿病肾病大鼠降钙素基因相关肽的影响研究 |
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| 引用本文： | 龚志刚,黄小华.有氧运动对糖尿病肾病大鼠降钙素基因相关肽的影响研究[J].四川体育科学,2014(1):33-35. |
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| 作者姓名： | 龚志刚 黄小华 |
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| 作者单位： | [1]江西师范大学体育学院,江西南昌330022 [2]湖州市南浔区中西医结合医院检验科,浙江湖州313009 |
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| 基金项目： | 江西师范大学青年成长基金（3926） |
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| 摘 要： | 目的：研究有氧运动对糖尿病肾病（DN）大鼠降钙素基因相关肽（CGRP）的影响。方法：链脉佐菌素（STZ）诱导糖尿病大鼠模型,随机分为糖尿病组（D）、糖尿病运动组（D＋E）、同时另设正常对照组（N）,有氧运动干预10周后,测定空腹血糖（FBG）、尿微量白蛋白（U-mAIb）、血浆和肾脏组织中内皮素（ET）和CGRP含量。结果：糖尿病大鼠U-mAIb增加,ET升高,CGRP下降,运动干预10周后,D＋E组DN大鼠U-mAIb较D组显著降低,ET显著下降,CGRP明显升高。结论：有氧运动对糖尿病大鼠肾脏病变有一定的保护作用,其部分机制可能是通过上调CGRP含量而实现的。
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| 关 键 词： | 有氧运动 糖尿病肾病 降钙素基因相关肽 大鼠 |
Effects of Aerobic Exercise on Calcitonin Gene-related Peptide in DN Rats |
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| GONG Zhi-gang;HUANG Xiao-Hua.Effects of Aerobic Exercise on Calcitonin Gene-related Peptide in DN Rats[J].Sichuan Sports Science,2014(1):33-35. |
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| Authors: | GONG Zhi-gang;HUANG Xiao-Hua |
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| Institution: | GONG Zhi-gang;HUANG Xiao-Hua;College of P.E., Jiangxi Normal University;Department of Medical Laboratory Science, Integrated Traditional and Western Medicine Hospital; |
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| Abstract: | Object： To investigate the effect of aerobic exercise on calcitonin gene-related peptide in diabetic nephropathy（DN） rats. Methods： STZ-induced diabetic rats were randomly divided into two groups： DN rats model group（D）,DN rats exercise intervene group（D＋E）,in addition,normal rats for control group（N）. All rats were fed for 10 weeks. The serum FBG, U-mAIb, ET and CGRP were measured. Results： compared with N group, The content of U-mAIb and ET in DN rats were significantly increased. The level of CGRP was markedly decreased; After the Exercise treatment,the serum CGRP, ET and U-mAIb changes of diabetic rats in the D＋E group were improved. Conclusion： Aerobic exercise could meliorate early kidney hy-perdynamic abnormality in DN rats,possess protective effect on kidney of diabetic rat whose mechanism may be associated partly with a UP-regulation of the CGRP level. |
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| Keywords: | Aerobic exercise Diabetic nephropathy Calcitonin gene-related peptide Rats |
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