| 不同低氧训练方式对红细胞调控T淋巴细胞免疫及亚群的影响 |
| |
| 引用本文： | 朱荣,张缨,王芳.不同低氧训练方式对红细胞调控T淋巴细胞免疫及亚群的影响[J].体育科学,2007,27(3):68-71. |
| |
| 作者姓名： | 朱荣 张缨 王芳 |
| |
| 作者单位： | 北京体育大学,北京,100084 |
| |
| 摘 要： | 观察不同低氧训练方式对红细胞调控T淋巴细胞免疫及亚群的影响。用低氧舱模拟4000m高原低氧环境（12．6％氧浓度），将50只SD雄性大鼠随机平分为5组：高住高训组（HiHi）、高住低训组（HiLo）、高住对照组（HiCo）、低住低训组（LoLo）和低住对照组（LoCo）。实验4周，每周6天游泳，1天休息，每天训练1．5h。实验结束后，同时取腹主动脉血，用流式细胞仪检测红细胞CD48、CD59荧光强度和T淋巴细胞CD2^＋％、CD3^＋％、CD4^＋％、CD8^＋％。结果发现，红细胞CD48、CD59表达和T淋巴细胞CD2^＋％、CD3^＋％、CD4^＋％、CD8^＋％大致趋势是HiHi组〈HiCo组〈HiLo组〈LoCo组〈LoLo组，各组间CD4^＋／CD8^＋比值无显著性差异（P〉0.05）。提示：1）低氧暴露可能会降低红细胞调控T淋巴细胞免疫能力；常氧环境中运动有可能促进红细胞调节T淋巴细胞免疫；2）低氧暴露和常氧环境中训练都有可能影响T淋巴细胞总数；3）不同低氧训练方式中CD4^＋／CD8^＋比值没有显著性差异。
|
| 关 键 词： | 低氧训练 红细胞 调控 T淋巴细胞免疫 T淋巴细胞亚群 鼠 动物实验 |
| 文章编号： | 1000-677X（2007）03-0068-04 |
| 修稿时间： | 2006-12-262007-02-11 |
The Effect of Modulation of Erythrocyte on Lymphocyte Immune Function and of Lymphocyte Subpopulations at Different Hypoxia Training |
| |
| ZHU Rong,ZHANG Ying,WANG Fang.The Effect of Modulation of Erythrocyte on Lymphocyte Immune Function and of Lymphocyte Subpopulations at Different Hypoxia Training[J].China Sport Science,2007,27(3):68-71. |
| |
| Authors: | ZHU Rong ZHANG Ying WANG Fang |
| |
| Institution: | Beijing Sport University, Beijing 100084, China. |
| |
| Abstract: | To observe the effect of regulation of erythrocyte on lymphocyte immune function and of Lymphocyte subpopulations at different hypoxia training(12.6%O2 ,simulated altitude of 4,000 m).50 male SD rats were divided into five groups randomly:HiHi,HiLo,HiCo,LoLo and LoCo groups for four weeks experiment with six days training per week,1.5hours everyday and one day rest in a week.At the end of experiment,flow cytometry was adopted to detect the expression in CD48,CD59 on erythrocyte and CD2,CD3,CD4,CD8 on T lymphocyte.There was a trend that their expression decreased,LoLo>LoCo>HiLo>HiCo >HiHi groups,and was not significant variability of CD4 /CD8 between different group.It is implied that the modulation of erythrocyte on T lymphocyte immune function weakened at hypoxic condition,but improved in normoxia training.Hypoxic exposure and training in normoxia could affect total lymphocyte count. |
| |
| Keywords: | different hypoxia training erythrocyte modulation T lymphocyte immune T lymphocyte subpopulations |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
