| 骨形态发生蛋白对膝内侧副韧带止点愈合影响的实验研究 |
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| 引用本文： | 王健全,田得祥,余家阔.骨形态发生蛋白对膝内侧副韧带止点愈合影响的实验研究[J].体育科学,2001,21(3):55-58,70. |
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| 作者姓名： | 王健全 田得祥 余家阔 |
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| 作者单位： | 北京医科大学,运动医学研究所,北京,100083 |
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| 基金项目： | 国家自然科学基金资助项目(基金号:39270745). |
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| 摘 要： | 为了了解骨形态发生蛋白(BMP)在关节韧带愈合中的作用,将8只普通家兔随机分为两组,采取自体对照的方法,手术制作膝内侧副韧带上止点断裂后原位修复模型,将部分纯化的牛骨形态发生蛋白植入韧带上止点周围,对侧植入牛血清白蛋白(BSA)作为对照.结果发现BMP侧韧带止点周围结缔组织和骨增生明显,在30 d组BMP侧止点周围新生骨量较BSA侧明显增多(P《0.01),并在韧带与骨之间出现类似末端结构样连接.因此本研究认为BMP能够通过诱导新骨生成和促进纤维结缔组织的生成来促进韧带与骨之间的早期牢固愈合.
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| 关 键 词： | 止点愈合 实验研究 运动医学 骨形态发生蛋白 膝内侧副韧带 运动损伤 原位修复模型 |
| 文章编号： | 1000-677X(2001)03-0055-04 |
Effect of Bovine Bone Morphogenetic Protein on the Healing of the Torn Medial Collateral Ligament in Rabbit |
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| WANG Jian quan et al.Effect of Bovine Bone Morphogenetic Protein on the Healing of the Torn Medial Collateral Ligament in Rabbit[J].China Sport Science,2001,21(3):55-58,70. |
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| Authors: | WANG Jian quan |
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| Abstract: | To understand bone morphogenetic protein (BMP)'s effect on the healing of the torn medial collateral ligament, eight common rabbits were randomly assigned to twenty days and thirty days groups. For each rabbit, both medial collateral ligaments were cut off from their femoral attachments and rebuilt in situ. In one knee, partially purified bovine BMP (bBMP) was implanted into the bone defect in which the rebuilt medial collateral ligament was inserted, and bovine serum albumin (BSA) was implanted into the contralateral knee for control. The results showed that BMP promoted the proliferation of fibrous tissue and bone and induced ectopic bone formation. In thirty days group, the insertion of ligament progress from fibril to fibrocartilage to mineralied fibrocartilage, as a normal insertion do. These results indicated that BMP could promote the healing of the torn insertion of medial collateral ligament. |
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| Keywords: | sports med bone protein articular ligament ligament pathology rabbit |
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