| 肌酸补充与骨骼肌糖代谢 |
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| 引用本文： | 朱蔚莉,李可基.肌酸补充与骨骼肌糖代谢[J].体育科学,2006,26(1):71-73. |
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| 作者姓名： | 朱蔚莉 李可基 |
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| 作者单位： | 1. 首都体育学院,解剖生力教研室,北京,100088
2. 北京大学,医学部,营养与食品卫生学系,北京,100083 |
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| 基金项目： | 北京市教委科技发展计划项目 |
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| 摘 要： | 口服补充肌酸可使骨骼肌的肌酸摄取增强，但又受胰岛素水平、运动训练状况及肌纤雏型等多种因素的影响。肌酸补充后骨骼肌糖代谢能力增强，主要表现为血糖降低、骨骼肌糖原合成增强、骨骼肌葡萄糖转运蛋白4的表达上调，以及柠檬酸合酶活性升高。肌酸增强骨骼肌糖代谢的机制，可能与细胞体积增大而引发的细胞内信号转导改变有关。
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| 关 键 词： | 肌酸 葡萄糖 骨骼肌 代谢 |
| 文章编号： | 1000-677X（2006）01-0071-03 |
| 收稿时间： | 2005-09-05 |
| 修稿时间： | 2005-09-052005-11-13 |
Creatine Supplement and Glucose Metabolism in Skeletal Muscle |
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| ZHU Wei-li,LI Ke-ji.Creatine Supplement and Glucose Metabolism in Skeletal Muscle[J].China Sport Science,2006,26(1):71-73. |
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| Authors: | ZHU Wei-li LI Ke-ji |
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| Institution: | 1. Department of Anatomy, Capital Institute of Physical Education, Beijing 100088, China; 2. Department of Nutrition, Peking University Health Science Cerntre, Beijing 100083, China |
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| Abstract: | Oral supplement can enhance the uptake of creatine in skeletal muscle. However, it is influenced by many factors such as the level of insulin, training condition and fiber type. The improvement of glucose metabolism after creatine supplement is associated with lower level of blood glucose, glycogen synthesis improvement, up-regulation of glucose transporter 4 and increased citrate synthase activity. The mechanism of glucose metabolism improvement after creatine supplement is related with signal transduction change induced by increased skeletal muscle cell volume. |
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| Keywords: | creatine glucose skeletal muscle metabdism |
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