| 过度训练对大鼠心肌线粒体内钙、MDA及磷脂酶A2的影响 |
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| 引用本文： | 刘铁民,张玉泉,田坤.过度训练对大鼠心肌线粒体内钙、MDA及磷脂酶A2的影响[J].浙江体育科学,2002,24(3):44-48. |
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| 作者姓名： | 刘铁民 张玉泉 田坤 |
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| 作者单位： | 聊城师范学院,体育学院生化室,山东,聊城,252059 |
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| 基金项目： | 山东省教育厅科研资助项目,项目编号:J01L02. |
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| 摘 要： | 为了研究过度训练状态下心肌组织损害的变化规律，采用建立一般训练和过度训练大鼠模型，应用形态学手段和分子生化技术，对训练后两组大鼠心肌线粒体内钙含量、脂质过氧化反应产物丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-Px)、超氧化物歧化酶（SOD）、心肌组织匀浆内酸性磷酸酶（Acid Phosphatase,ACP）和β莆萄糖醛酸酶（Beta-glucronidase)、磷脂酶A2（PLA2）等指标做了定位和定量研究。结果表明，第4周末，一般训练组和过度训练组大鼠心肌线粒体内钙含量、MDA和GSH-Px、SOD、PLA2活性和心肌ACP、β-葡萄糖醛酸酶的活性未见异常改变明显降低；第8周末，心肌ACP和β-葡萄糖醛酸酶明显增加。结果提示过度训练后心肌线粒体的结构和功能产生了明显变化，这些变化可能是引起过度训练状态下心肌损伤的主要原因。
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| 关 键 词： | 过度训练 心肌线粒体 显微镜检查 自由基损伤 磷脂酶A2 |
| 文章编号： | 1004-3624(2002)03-0044-05 |
| 修稿时间： | 2002年2月9日 |
Effects of overtraining on the myocardial acid phosphatase,beta-glucuronidase,and the mitochondrial Ca,MDA,PLA2 in rats |
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| Liu tie-min,Zhang yu-quan,Tian kun.Effects of overtraining on the myocardial acid phosphatase,beta-glucuronidase,and the mitochondrial Ca,MDA,PLA2 in rats[J].Zhejiang Sport Science,2002,24(3):44-48. |
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| Authors: | Liu tie-min Zhang yu-quan Tian kun |
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| Abstract: | To investigate the effects of overtraining on the myocardial acid phosphatase,beta-glucuronidase,and the mitochondrial Ca,MDA,SOD,GSH,PLA 2 electron microscope technique and biochemistry technique were used in overtraining group(OG)and control group(CG)rats.There was no abnormal changes on the myocardial acid phosphatase,beta-glucuronidase,and the mitochondrial Ca,MDA,SOD,GSH-Px,LPA 2 in OG and CG at the end of 4 weeks(P>0 05),but the mitochondrial Ca,MDA content and myocardial acid phosphatase and beta-glucuronidase and mitochondrial phospholipase A2 activities were increased significantly and the GSH-Px?SOD activities was decreased significantly in OG at the eng of 8 weeks(P<0 01).The results indicated that the myocardial was damaged,It is concluded that overtraining could exert effects on the myocardial and myocardil mitochondrial. |
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| Keywords: | overtraining myocardial mitochondrial microscopy free radicle phospholipase A 2 |
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