| 有氧运动与抗阻运动对非酒精性脂肪肝病疗效差异的Meta分析 |
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| 引用本文： | 李阳,王爱文,韩娜娜,余蕾,黄晖明.有氧运动与抗阻运动对非酒精性脂肪肝病疗效差异的Meta分析[J].浙江体育科学,2021(1):75-86. |
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| 作者姓名： | 李阳 王爱文 韩娜娜 余蕾 黄晖明 |
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| 作者单位： | 宁波大学体育学院;宁波大学大健康研究院 |
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| 基金项目： | 国家社会科学基金项目(18BTY100);宁波大学科研创新基金项目(IF2020046)。 |
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| 摘 要： | 目的:探索有氧运动和抗阻运动两种常见运动方式对非酒精性脂肪肝病(NAFLD)患者内脏脂肪、肝功能与脂代谢治疗效果对比,为患者选择适宜的运动方案提供依据。方法:检索PubMed、Web of Science、中国知网等数据库,搜集随机对照试验文献,采用Cochrane偏倚风险评估文献质量,Review Manager 5.3软件meta分析。结果:1)内脏脂肪与脂代谢方面,有氧运动与抗阻运动之间的疗效差异不具有统计学意义;2)肝功能方面,肝功能天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)与氨酰转移酶(GGT)在两种运动间的疗效差异不具有统计学意义;进一步亚组分析显示,有氧运动对AST在“年龄<52岁”、“BMI≥28”、“干预频次为3次/周”、“干预周期≤12周”亚组中改善效果比抗阻运动好;对ALT的改善在“BMI≥28”、“干预频次为3次/周”亚组中效果更佳。结论:有氧运动与抗阻运动相比,对NAFLD患者内脏脂肪、肝功能与脂代谢治疗效果均无差异,两种运动方式的干预效果相近;但不同亚组仍表现出差异,有氧运动组AST在低龄、高BMI、短干预周期和短干预频次组改善效果更佳,ALT在低龄、短干预周期组具有更好效果。提示患者应根据自身心肺功能、肌肉力量及自身运动情况等,选择适宜自己的运动进行,而当患者需要改善AST与ALT时,建议选择有氧运动干预方式。
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| 关 键 词： | 非酒精性脂肪肝(NAFLD) 有氧运动 抗阻运动 治疗差异 META分析 |
Meta-analysis of the Effect of Different Exercise Methods on Non-alcoholic Fatty Liver Disease |
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| LI Yang,WANG Ai-wen,HAN Na-na,YU Lei,HUANG Hui-ming.Meta-analysis of the Effect of Different Exercise Methods on Non-alcoholic Fatty Liver Disease[J].Zhejiang Sport Science,2021(1):75-86. |
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| Authors: | LI Yang WANG Ai-wen HAN Na-na YU Lei HUANG Hui-ming |
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| Institution: | (School of Physical Education,Ningbo University,Ningbo 315211,China;Research Academy of Grand Health,Ningbo University,Ningbo 315211,China) |
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| Abstract: | Objects:Explore the effects of aerobic exercise and resistance exercise on the treatment of visceral fat,liver function and lipid metabolism in patients with non-alcoholic fatty liver disease(NAFLD),and provide a basis for patients to choose an appropriate exercise program.Methods:Search for databases such as PubMed,Web of Science,and China Knowledge Network,collect randomized controlled trials,evaluate the quality of the literature using Cochrane bias risk,and meta-analysis were performed using Review Manager 5.3 software.Results:(1)In terms of visceral fat and lipid metabolism,the difference between aerobic exercise and resistance exercise was not statistically significant;(2)in terms of liver function,aspartate aminotransferase(AST),alanine aminotransferase(ALT)and gamma glutamyl transpeptidase(GGT)had no statistically significant difference in the efficacy of the two exercises.Further subgroup analysis showed that the effect of aerobic exercise in subgroups of"age<52","BMI≥28","frequency of intervention for 3 times/week","12 weeks or less intervention cycle"at AST were better than resistance exercise;meanwhile,the improvement of ALT in"BMI≥28","frequency of intervention for 3 times/week"group were better.Conclusions:Compared with resistance exercise,aerobic exercise showed no or unclear differences on visceral fat,liver function and lipid metabolism in patients with NAFLD.The intervention effect of the two exercise modes was similar.However,the efficacy of liver function was still different in different subgroups.AST improved better in the group with low age,high BMI,short intervention period and short intervention frequency,and ALT improved better in the group with low age and short intervention period.Suggesting that patients should choose their own exercise according to their cardiopulmonary function,muscle strength and their own exercise conditions.When patients need to improve AST and ALT,it is recommended to choose Aerobic exercise intervention methods. |
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| Keywords: | non-alcoholic fatty liver(NAFLD) aerobic exercise resistance exercise therapeutic discrepancy meta-analysis |
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