| 黄芪生药对运动大鼠心肌自由基损伤的研究 |
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| 引用本文： | 马先英,孔喜良.黄芪生药对运动大鼠心肌自由基损伤的研究[J].中国体育科技,2007,43(5):132-135. |
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| 作者姓名： | 马先英 孔喜良 |
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| 作者单位： | 1. 山东财政学院,山东,济南,250014
2. 曲阜师范大学,体育科学学院,山东,曲阜,273165 |
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| 摘 要： | 目的:通过观察大鼠心肌自由基代谢变化,探讨灌服黄芪生药对训练大鼠心肌损害的保护作用机制。方法:选取雄性Wistar大鼠按体重灌服中药煎剂,采用游泳训练方式分别于安静、力竭即刻、力竭恢复12h状态下,取大鼠心肌组织测定MDA、SOD、GSH、GOT、PLA_2活性。结果:与对照组相比,服药组大鼠力竭时间延长,有显著性差异(P<0.01)。安静状态下服药组GSH含量显著高于对照组(P<0.05),SOD含量显著高于对照组(P<0.01)。大鼠力竭后即刻MDA含量、SOD活性、PLA_2活性与对照组有显著性差异(P<0.01)。力竭运动恢复12h后MDA含量、GSH含量、PLA_2活性与时照组有显著性差异(P<0.01)。结论:黄芪能够有效抑制脂质过氧化反应,提高机体在不同功能状态下的抗氧化能力,减轻心肌损伤,从而延长大鼠运动时间,推迟疲劳的发生。
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| 关 键 词： | 黄芪 自由基 心肌 鼠 动物实验 |
| 文章编号： | 1002-9826(2007)05-0132-04 |
| 修稿时间： | 2007年3月8日 |
Study of Astragalus hoangtchy on the Free Radicals Injury of Cardiac Muscle of Exercise Rat |
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| MA Xian-ying,KONG Xi-liang.Study of Astragalus hoangtchy on the Free Radicals Injury of Cardiac Muscle of Exercise Rat[J].China Sport Science and Technology,2007,43(5):132-135. |
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| Authors: | MA Xian-ying KONG Xi-liang |
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| Abstract: | With the observation of the changes of free radical metabolism of cardiac muscle,this paper discusses the functional mechanism of astragalus hoangtchy that feed to protect the cardiac muscle of the rat in training.The male Wistar white rat is selected and be fed the cooked Chinese medicine astragalus hoangtchy proportioned to their weight,training them to swim and taking their cardiac muscle tissues respectively at rest,right after exhausting and 12 hours after exhaust to determine MDA,SOD,GSH,GOT and PLA_2 activity.The result shows that compared with the control group,the experimental Wistar's exhaustive time is postponed obviously(P<0.01). At the rest,the experimental group's GSH and SOD content are ohviously higher than the con- trol group(P<0.05,P<0.01 respectively);right after exhausting,the mouse's MDA content, SOD activity and PLA_2 activity are different apparently(P<0.01),GSH content increases great- ly (P<0.05);12 hours after exhausting,the experimental group's MDA,GSH contents and PLA_2 activity are quite different from the control group(P<0.01),GOT activity increases appar- ently(P<0.05).It concludes that astragalus hoangtchy can suppress lipin peroxidation,improve the anti-oxidized ability of organisms,promote the function of the cardiac muscle,decrease the harm to the cardiac muscle,prolong the duration of movement and postpone the appearance of fa- tigue. |
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| Keywords: | Astragalus hoangtchy free radical cardiac muscle rats animal experiment |
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