| GnRH-R在大鼠递增负荷训练中的表达及与性激素的关系 |
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| 引用本文： | 王人卫,陆爱云,郭仕达,高勇,蔡斌,段子才.GnRH-R在大鼠递增负荷训练中的表达及与性激素的关系[J].上海体育学院学报,2001,25(2):26-30. |
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| 作者姓名： | 王人卫 陆爱云 郭仕达 高勇 蔡斌 段子才 |
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| 作者单位： | 上海体育学院体育保健康复系, |
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| 基金项目： | 教育部博士点基金资助课题；第六届全国体育科学大会入选论文 |
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| 摘 要： | 采用动物实验研究法，对促性腺素释放激素受体(GnRH-R)在大鼠递增负荷训练中的表达及与性激素的关系进行分析。结果显示，长期大强度负荷使Ta组大鼠垂体GnRH-R表达明显低于C组，且同时伴有LH、E2、P、T明显低于C组，FSH也低于C组；但是Ta组大鼠下丘脑、血浆β-EP明显高于C组。休息1周后GnRH-R未见恢复。认为，长期大强度负荷使Ta组大鼠垂体GnRH-R自身调节发生紊乱，是引起AMI的重要因素之一；过高的β-EP抑制中枢GnRH分泌，是垂体GnRH-R表达减弱的主要抑制神经递质之一；推测AMI可能发生在下丘脑水平。
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| 关 键 词： | 促性腺素释放激素受体 大鼠 负荷训练 下丘脑 表达强度 性激素 |
| 文章编号： | 1000-5498(2001)02-0026-05 |
| 修稿时间： | 2001年1月5日 |
Expression of GnRH-R in Progressive Load Training
for Rats and Its Relation with Sex Hormone |
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| Wang Renwei,Lu Aiyun,Guo Shida,Gao Yong,Cai Bing,Duan Zicai.Expression of GnRH-R in Progressive Load Training
for Rats and Its Relation with Sex Hormone[J].Journal of Shanghai Physical Education Institute,2001,25(2):26-30. |
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| Authors: | Wang Renwei Lu Aiyun Guo Shida Gao Yong Cai Bing Duan Zicai |
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| Abstract: | By animal experiments, the present paper analyzes the expression of GnRH-R in progressive load training for rats and its relation with sex hormone. The results show that the pituitary GnRH-R of Group Ta's rats under the long-term high intensity load is obviously lower than that of Group C's rats. Meanwhile, LH, E2, P and T of Group Ta are significantly lower than that of Group Ta. Besides this, FSH of Group Ta is also lower than Group C. However, hypothalamus, and plasma β-EP of Group Ta are evidently higher than that of Group C. After a week's rest, there is no recovery in GnRH-R of Group Ta. It is obvious that the long term high intensity load brings about self-regulation disorder in pituitary GnRH-R of Group Ta's rats under the long-term high intensity load, which is one of the important factors in leading to AMI; overhigh β-EP would restrict the secretion of GnRH, which is one of the major factors in decreasing the expression of pituitary GnRH-R; it is inferred that AMI may occur in hypothalamus level. |
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| Keywords: | GnRH-R rat load training hypothalamus expression intensity sex hormone |
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