| 氟他胺加睾丸切除治疗晚期前列腺癌22例报告 |
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| 引用本文： | 王慎鸿.氟他胺加睾丸切除治疗晚期前列腺癌22例报告[J].科技通报,2001,17(3):71-73. |
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| 作者姓名： | 王慎鸿 |
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| 作者单位： | 浙江省中医院泌尿外科, |
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| 摘 要： | 为探讨提高晚期前列腺癌的治疗效果，回顾性研究22例晚期前列腺癌的临床资料，运用氟他胺加睾丸切除治疗前列腺癌，其中C2期8例，D1期9例，D2期5例。结果：显效17例，有效3例，死亡2例，总有效率达90．9％。结果表明氟他胺是一个单纯抗雄激素的非类固醇化合物，对前列腺组织靶细胞膜上的雄激素受体有特异性阻断作用，能抑制雄激素依赖性肿瘤细胞生长，切除睾丸能降低雄激素水平，两者产生协同作用，提高疗效。
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| 关 键 词： | 氟他胺 睾丸切除 前列腺癌 男性泌尿生殖系肿瘤 抗雄性激素药物 治疗 |
| 文章编号： | 1001-7119(2001)03-0071-03 |
| 修稿时间： | 2000年12月22 |
Orchiectomy with Oral Flutamide in Treating Advanced Prostate Carcinoma—Clinical Report of 22 Cases |
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| WANG Shen-hong.Orchiectomy with Oral Flutamide in Treating Advanced Prostate Carcinoma—Clinical Report of 22 Cases[J].Bulletin of Science and Technology,2001,17(3):71-73. |
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| Authors: | WANG Shen-hong |
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| Abstract: | To enhance the therapeutic outcome for advanced prostate carcinoma, the authors studied retrospectively 22 cases of advanced prostate carcinoma, which were treated by orchiectomy with oral Flutamide. Among 22 cases, state C 2 was 8, D 1 was 9,and D 2 was 5 respectively. Total effective rate was 90.9%, with 17 CR, 3 PR and 2 deaths. The result showed that the orchiectomy can lower the serum level of androgen, and Flutamide can block the male hormone receptor in the target cell membrane of prostate tissue, thereby inhibit the growth of androgen dependent tumor cells. Oral Flutamide cooperated with orchiectomy resulted in the ideal outcome. |
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| Keywords: | Flutamide orchiectomy prostate carcinoma |
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