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| 药物高通量亲合色谱筛选中定性定量模型的建立 | |
| 引用本文： | 刘白玲,李松军.药物高通量亲合色谱筛选中定性定量模型的建立[J].中国科学院研究生院学报,2006,23(1):31-38. |
| 作者姓名： | 刘白玲 李松军 |
| 作者单位： | 1. 中国科学院成都有机化学研究所,成都,610041 2. 中国科学院成都有机化学研究所,成都,610041;中国科学院研究生院,北京,100049 |
| 摘 要： | 通过对AC高通量筛选过程的分析，建立了AC技术筛选药物的定性及定量模型，为高通量药物筛选提供了必要的理论指导。 |
| 关 键 词： | 高通量药物筛选 亲合色谱筛选法 筛选原理与过程 定性定量模型 |
| 文章编号： | 1002-1175(2006)01-0031-08 |
| 修稿时间： | 2004年9月13日 |
Establishment of Qualitative and Quantitative Models for Affinity Chromatography-Based High-Throughput Screening |
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| LIU Bai-Ling,LI Song-Jun.Establishment of Qualitative and Quantitative Models for Affinity Chromatography-Based High-Throughput Screening[J].Journal of the Graduate School of the Chinese Academy of Sciences,2006,23(1):31-38. | |
| Authors: | LIU Bai-Ling LI Song-Jun |
| Institution: | 1 Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041; 2 Graduate School of Chinese Academy of Sciences, Beijing 10039 |
| Abstract: | The affinity chromatography (AC) technique,based on the affinity principle of ligand and receptor, as well as the specificity and reversibility of their combination, is a considerably efficient technique for high throughput screening(HTS) of drugs. Since AC shows obviously the dynamical characters, associating and dissociating between ligands and receptors present in its column, it can present much more information than other related techniques. The information contained by its eluting curve reveals directly the interaction of ligand-target and its quantitative characterization, thereby facilitating drug discovery. Based on the analysis of AC-based HTS, the present study establishes a series of qualitative and quantitative models. Because of their usability, these models are normally expected to play a positive role in the future for guiding the process of drug screening. |
| Keywords: | high throughput screening of drugs affinity chromatography screening principle and process qualitative and quantitative models |
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