Preliminary studies on the hypoglycemic effect of <Emphasis Type="Italic">Peganum harmala</Emphasis> L. Seeds ethanol extract on normal and streptozotocin induced diabetic rats |
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| Authors: | Amar B Singh J P Chaturvedi T Narender Arvind K Srivastava |
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| Institution: | (1) Biochemistry, Central Drug Research Institute, Lucknow, 226001, India;(2) Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, 226001, India;(3) Biochemistry Division, Central Drug Research Institute, Lucknow, U.P., 226001, India |
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| Abstract: | Peganum harmala L. (Zygophyllaceae) is a traditional medicine used for the treatment of variety of human ailments, including
antidepression, hallucination, antileishmaniasis etc. We report for first time the hypoglycemic activity of the ethanolic
extract of this plant at two dose levels of 150 and 250mg/kg bw in sucrose challenged normal as well as in rats with streptozotocin
induced diabetes. The oral administration of ethanolic extract causes maximum fall of blood glucose level to 22.9% (p<0.05)
and 29.4% (p<0.01) respectively with the two doses in normal and 30.3% (p<0.01) and 48.4% (p<0.001) in diabetic rats. The
standard drug metformin treated group showed 28.0% (p<0.01) and 45.5% (p<0.001) respectively in normal and diabetic rats.
The above results show that the ethanolic extract of P. harmala is as effective as metformin in reducing the blood glucose
levels of normoglycemic and streptozotocin-induced diabetic rats. |
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| Keywords: | Peganum harmala Hyperglycemic Streptozotocin induced diabetic rats Sucrose challenged |
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