An opium alkaloid-papaverine ameliorates ethanol-induced hepatotoxicity: Diminution of oxidative stress |
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| Authors: | Ramesh Chandra Ritu Aneja Charu Rewal Rama Konduri Sujaka K Dass Shefali Agarwal |
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| Institution: | (1) Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, 110007 Delhi, India;(2) Department of Chemistry, University of Delhi, 110007 Delhi, India |
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| Abstract: | In this communication, we show the modulatory potential of papaverine, an opium alkaloid and a well known vasodilator agent
on the ethanol-induced hepatic oxidative stress in male Wistar rats. Ethanol treatment (50% v/v) enhanced lipid peroxidation
significantly accompanied by a decline in the activities of glutathione peroxidase (G-Px), glutathione reductase (GR) and
depletion in levels of hepatic glutathione (GSH). Ethanol administration increased hepatic glutathione-s-transferases (GST).
Enhanced lipid peroxidation induced by ethanol was significantly reduced when papverine was coadministered (P<0.05). In addition,
the depleted levels of glutathione and inhibited activities of G-Px and GR recovered significantly (P<0.05) levelling off
to control values on co-exposure. Papaverine (200 mg/kg bw) effectively antagonised the ethanol-induced lipid peroxidation
and impaired glutathione levels and glutathione dependent enzyme systems. Our results suggest that papaverine is an effective
chemopreventive agent in the liver and may suppress the ethanol-induced hepatotoxicity. |
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| Keywords: | Papaverine Lipid Peroxidation Glutathione Ethanol Oxidative Stress |
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