Plasma oxidant-antioxidant status in different respiratory disorders |
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| Authors: | Raghunath R Rai Madhavi S Phadke |
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| Institution: | (1) Department of Biochemistry, Lokmanya Tilak Municipal Medical College, Sion, 400022 Mumbai, India;(2) 727 Dhanwantari Society, Deonar Municipal Colony, ‘B’ wing, Sector II Plot 3&4, 400043 Mumbai, India |
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| Abstract: | This study confirms the fact that in different respiratory disorders, the status of plasma oxidants and antioxidants shifts
from normal. The status of oxidants in plasma as represented by malondialdehyde (MDA) levels increased significantly in the
conditions of chronic obstructive pulmonary disease (COPD), emphysema, bronchiectasis and bronchial asthma. The two vitamin
antioxidants vitamin C and vitamin E showed decreased levels than in controls. In patients with COPD the endogenous antioxidant
viz. reduced glutathione (GSH) estimated from whole blood was comparable to that of control group, whereas in patients with
emphysema, bronchiectasis and bronchial asthma, GSH concentration was increased to that of control group. The activity of
enzyme superoxide dismutase (SOD) was significantly decreased in all study groups. Pulmonary function tests were found to
have no correlation with MDA and antioxidants |
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| Keywords: | Vitamin antioxidants Endogenous antioxidants Respiratory disorders MDA |
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