Effect of ethanol on liver antioxidant defense systems: Adose dependent study |
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| Authors: | Subir Kumar Das D M Vasudevan |
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| Institution: | 1. Department of Biochemistry, Amrita Institute of Medical Sciences, 682 026, Cochin, Kerala
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| Abstract: | Alcohol induced oxidative stress is linked to the metabolism of ethanol. In this study it has been observed that administration
of ethanol in lower concentration caused gain in body and liver weight. while higher concentration of ethanol caused lesser
gain in body and liver weight. Ethanol treatment enhanced lipid peroxidation significantly, depletion in levels of hepatic
glutathione and ascorbate, accompanied by a decline in the activities of glutathione peroxidase and glutathione reductase,
and increased in hepatic glutathione s-transferase activity. Interestingly catalase activity increases in lower concentration
of ethanol exposure, and decreased in higher concentration. Superoxide dismutase activity was also increased on ethanol exposure.
But, ethanol feeding did not show any effect on glucose-6-phosphate dehydrogenase activity. Ethanol ingestion perturbs the
antioxidant system in a dose and time dependent manner. |
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| Keywords: | Ethanol Antioxidants Oxidative stress Glutathione Superoxide dismutase |
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