Erythrocyte glutathione status in human visceral leishmaniasis |
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| Authors: | D P Neupane S Majhi L Chandra S Rijal Nirmal Baral |
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| Institution: | (1) Department of Biochemistry, B. P. Koirala Institute of Health Sciences, Dharan, Nepal;(2) Department Medicine, B. P. Koirala Institute of Health Sciences, Dharan, Nepal |
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| Abstract: | A glutathione redox cycle is a major antioxidant defense system for the detoxification of reactive oxygen species within erythrocytes.
Reactive oxygen species such as superoxide anions, hydrogen peroxide and hydroxyl radicals are generated as a host defense
mechanism for killing of engulfed Leishmania donovani, a causative agent of visceral leishmaniasis, are capable of damaging
lipids and other biomolecules when produced in excess. Erythrocytes are most vulnerable to Reactive oxygen species. In present
study we aimed to evaluate erythrocyte reduced glutathione (GSH) levels as an antioxidant and erythrocyte malondialdehyde
(MDA) as a marker of lipid peroxidation. The study included twenty-five Visceral leishmaniasis patients and they were followed
up after their complete chemotherapy with antileishmanial drugs (sodium stibogluconate) for 30 days. Forty six age and sex
matched healthy individuals were taken as controls. GSH levels in erythrocytes of visceral leishmaniasis patients were increased
in spite of significant increased erythrocyte MDA as compared to controls. Whereas erythrocyte GSH and MDA levels of follow
up patients were decreased as compared to patients before treatment groups. We concluded that visceral leishmaniasis patients
are in oxidative stress which most likely induces the endogenous antioxidant such as GSH or its poor utilization by cells. |
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| Keywords: | Glutathione Malondialdehyde Visceral Leishmaniasis |
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