Acute and chronic toxicity studies on partially purified hypoglycemic preparation from water extract of bark ofFicus bengalensis |
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| Authors: | S Gupta R Shukla K M Prabhu S Aggrawal U Rusia P S Murthy |
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| Institution: | (1) Department of Biochemistry, University College of Medical Sciences and GTB Hospital, Shahdara, 110 095 Delhi;(2) Pathology, University College of Medical Sciences and GTB Hospital, Shahdara, 110 095 Delhi;(3) B-164, Sector 14, 201301 Noida, UP |
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| Abstract: | Acute and chronic toxicity studies were conducted to assess toxicity of a partially purified preparation from the water extract
of the bark ofFicus bengalensis, which was demonstrated in our earlier studies to have significant hypoglycemic and hypocholesteroiemic effect on alloxan
induced, mild and severe diabetes in rabbits. LD50 of this preparation was found to be ∼1 gm/kg in rats when given orally. For chronic toxicity studies 3 doses of aqueous preparation
were given to 3 groups of rats. First group received 5 times ED50 (50 mg/kg), second group 10 times ED50 (100 mg/kg) and the third group 15 times ED50 (150 mg/kg) for 3 months. Fourth group which served as control was given water. After three months, blood was collected for
studying biochemical and hematological parameters. Blood glucose, serum cholesterol, liver and kidney function tests, haemoglobin,
total and differential leukocyte count were determined. Animals were sacrificed and histopathological examination of liver,
heart and kidneys was carried out. Results of the study showed that partially purified preparation fromFicus bengalensis is not toxic by all the above mentioned parameters. |
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| Keywords: | Ficus bengalensis hypoglycemic compound acute and chronic toxicity |
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