Antidiabetic effect ofT. arjuna bark extract in alloxan induced diabetic rats |
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| Authors: | B Ragavan S Krishnakumari |
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| Institution: | (1) Department of Biochemistry, PSG College of Arts and Science, 641 029 Coimbatore;(2) Lecturer (SG) in Biochemistry, Kongunadu Arts and Science College, 641 029 Coimbatore |
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| Abstract: | The present study was carried out to evaluate the antidiabetic effect of T. arjuna stembark extract and to study the activities
of hexokinase, aldolase and phosphoglucoisomerase, and gluconeogenic enzymes such as glucose-6-phosphatase and fructose-1,6-diphosphatase
in liver and kidney of normal and alloxan induced diabetic rats. Oral administration of ethanolic extract of bark (250 and
500mg/kg body weight) for 30 days, resulted in significant decrease of blood glucose from 302.67±22.35 to 82.50±04.72 and
in a decrease in the activities of glucose-6-phosphatase, fructose-1,6-disphosphatase, aldolase and an increase in the activity
of phosphoglucoisomerase and hexokinase in tissues. However, in the case of 250 mg/kg body weight of extract, less activity
was observed. The study clearly shows that the bark extract ofT. arjuna possesses potent antidiabetic activity. |
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| Keywords: | Terminalia arjuna gluconeogenic alloxan aldolase antidiabetic |
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