Adenosine deaminase and C-reactive protein in cerebrospinal fluid for differential diagnosis of tubercular meningitis in children |
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| Authors: | Shrish Bhatnagar Farzana K Beig Ashraf Malik |
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| Institution: | (1) Department of Pediatric Gastroenterology, SGPGIMS, Lucknow, India;(2) Department of Pediatrics, Jawahar Lal Nehru Medical College, Aligarh Muslim University, Aligarh, India;(3) Department of Pediatric Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow. U.P., 226017, India |
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| Abstract: | Adenosine deaminase and C-reactive protein in CSF were assessed in 72 cases of Tubercular meningitis, 24 cases of partially
treated pyogenic meningitis, 20 cases of Aseptic meningitis and 8 cases of febrile seizures. Mean Adenosine deaminase value
was 12.12±3.13 IU/L for Tubercular meningitis group. It was significantly higher (p<0.001) as compared to partially treated
pyogenic meningitis (5.39±2.70 IU/L) and aseptic meningitis (1.92±0.56 IU/L) groups. A combination of clinical criteria along
with biochemical test of Adenosine deaminase and C-reactive protein in CSF increased the sensitivity of diagnosing Tubercular
meningitis and differentiating it from other forms of meningitis at an early stage. |
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| Keywords: | Adenosine deaminase and C-reactive protein in CSF Tubercular meningitis Children |
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