Evaluation of Oxidative Stress and Antioxidant Status in Pregnant Anemic Women |
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| Authors: | Amit Kumar Mani Tiwari Abbas Ali Mahdi Fatima Zahra Sudarshna Chandyan Vinod Kumar Srivastava Mahendra P Singh Negi |
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| Institution: | (1) Department of Biochemistry, C.S.M. Medical University, Lucknow, India;(2) Department of Obstetrics and Gynecology, Era’s Lucknow Medical College and Hospital, Lucknow, India;(3) Department of Biochemistry, Bundelkhand University, Jhansi, India;(4) Department of Community Medicine, C.S.M. Medical University, Lucknow, India;(5) Biometry Division, Central Drug Research Institute, Lucknow, India;(6) Medical Elementology and Free Radical Biology Lab, Department of Biochemistry, King George’s Medical University, Lucknow, 226003, India; |
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| Abstract: | The present study was conducted to investigate the oxidant–antioxidant status in iron deficient pregnant anemic women. One
hundred thirty pregnant women with iron deficiency anemia (IDA) were divided into three groups, namely mild (50), moderate
(50) and severe (30) anemic along with pregnant healthy women as controls (50). The complete blood count, plasma lipid peroxidation
products, enzymatic and non-enzymatic antioxidants were measured according to respective protocols. The levels of complete
blood count, iron, ferritin along with antioxidant enzymes namely catalase, superoxide dismutase, glutathione peroxidase,
glutathione reductase and reduced glutathione were significantly reduced in all IDA groups. However, the level of oxidized
glutathione, lipid peroxides, protein carbonyls, conjugated dienes were found significantly increased in all anemic patients.
Antioxidant vitamins, namely C, E and A were also found significantly decreased in IDA patients. On the basis of our results,
it may be concluded that IDA tends to increase the pro-oxidant components, which may result in various complications including
peroxidation of vital body molecules resulting in increased risk for pregnant women as well as fetus. |
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| Keywords: | Iron deficiency anemia Oxidants Antioxidants Pregnancy |
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