Circulating peptide and steroid hormone levels in patients with breast cancer |
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| Authors: | Lakshmi Krishnamoorthy Elizabeth Zachariah P G Ramaswamy N Anantha |
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| Institution: | 1. Department of Biochemistry, Kidwai Memorial Institute of Oncology, Hosur Road, 560 029, Bangalore
2. St. John’s Medical College and Hospital, 560 029, Bangalore
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| Abstract: | Circulating levels of gonadotropins (FSH,LH), prolactin (PRL), estradiol and progesterone were measured by radioimmunoassay
in the sera of 60 patients with histopathologically proven breast cancer. 30 patients belonged to the post and 30 to the premenopausal
group. 30 healthy women, 15 each in the pre and post menopausal groups served as controls for the study.
Prolactin was elevated in 33% and 26% of pre and post menopausal breast cancer patients respectively. Lower levels of estradiol
and progesterone were observed during the luteal phase of the menstrual cycle in premenopausal breast cancer patients. Among
postmenopausal patients with breast cancer, LH was elevated in 32%, FSH in 15% and estradiol in 30% of the patients studied. |
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| Keywords: | hormones breast cancer gonadotropins prolactin estradiol progesterone |
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