Study of glycemic profile of Cajanus cajan leaves in experimental rats |
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| Authors: | Dolly Jaiswal Prashant Kumar Rai Amit Kumar Geeta Watal |
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| Institution: | (1) Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Lab, Department of Chemistry, University of Allahabad, Allahabad, 211 002, India;(2) Medicinal Research Lab and Nucleic Acid Research Laboratory Department of Chemistry, University of Allahabad, Allahabad, 211002, India |
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| Abstract: | The present study deals with the evaluation of glycemic profile of aqueous extract of Cajanus cajan leaves in streptozotocin induced type 2 diabetic rats. Single oral administration of graded doses of aqueous extract of Cajanus
cajan leaves showed significant increment of 14.3 % in fasting blood glucose levels of normal rats. The sub diabetic and mild diabetic
models have also shown hyperglycemic effect from the same variable doses of the extract. The dose of 1000 mg/kg showed the
maximum rise of 17.1, 71.2 and 50.7 % in Blood glucose levels of normal, sub and mild diabetic rats respectively during glucose
tolerance test. The study of leaves was taken into consideration on the basis of earlier reported hypoglycemic activity of
Cajanus cajan seeds. However the results observed were found just opposite and therefore it may be useful in controlling hypoglycemia,
occasionally caused due to excess of insulin and other hypoglycemic drugs. |
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| Keywords: | Cajanus cajan Fabiaceae Pigeon pea Diabetes mellitus Hyperglycemic |
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