Serum markers for early diagnosis of non-‘Q’ wave and ‘Q’ wave myocardial infarction |
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| Authors: | Alka Singh Sheila Uthappa V Govindaraju T Venkatesh |
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| Institution: | (1) Department of Biochemistry and Biophysics, St. John's Medical College, SJNAHS, 560 034 Bangalore;(2) Jayadeva Institute of Cardiology, 560 002 Bangalore |
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| Abstract: | The present study conducted on twenty-five uncomplicated cases of acute myocardial infarction diagnosed by clinical and electrocardiographic
findings indicated significantly increased level of cardiac Troponin-T and increased activities of the enzymes total creatine
kinase, creatine kinase-MB, aspartate transaminase and lactate dehydrogenase as compared to the twenty-five healthy control
subjects. The level of cardiac Troponin-T and the activities of the enzymes total creatine kinase, creatine kinase-MB, aspartate
transaminase and lactate dehydrogenase was found to be higher in “Q” wave myocardial infarction patients as compared to the
non-“Q” wave and the controls. Since cardiac Troponin-T has been shown to increase in unstable angina and renal failure without
cardiac disease and creatine kinase-MB activity has been found to be normal in patients with unstable angina and increase
very slightly in patients with renal failure, it was concluded that a combination of cardiac Troponin-T and creatine kinase-MB
activity was sufficient for the early diagnosis of acute myocardial infarction. |
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| Keywords: | AMI cardiac Troponin-T serum cardiac markers |
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