Evidence for oxidative stress in osteoarthritis |
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| Authors: | M Maneesh H Jayalekshmi T Suma S Chatterjee A Chakrabarti T A Singh |
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| Institution: | (1) Dept of Pharmacology, Sikkim Manipal Institute of Medical Sciences, Gangtok;(2) Department of Biochemistry, Sikkim Manipal Institute of Medical Sciences, 737102 Gangtok, Sikkim |
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| Abstract: | Evidence of increased oxidative stress in patients of osteoarthritis in comparison with healthy control subjects was investigated
by measuring the thiobarbituric acid reactive substances (TBARS), vitamin C, reduced glutathione (GSH) and the activities
of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) in erythrocytes. It was observed that osteoarthritis
patients were more susceptible to oxidative damage than controls as evident from increased TBARS and decreased ascorbic acid,
GSH, catalase and GPx in erythrocytes. Significant increase in SOD activity found in patients might be an adaptive response.
With the understanding of the role of antioxidants in arthritis, it is becoming increasingly clear that these agents seem
to be beneficial in osteoarthritis. |
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| Keywords: | Oxidative stress Antioxidant Osteoarthritis |
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