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The Role of 25-Hydroxy Vitamin D Deficiency in Iron Deficient Children of North India |
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| Authors: | Shikha Sharma Rahul Jain Pradeep Kumar Dabla |
| Institution: | .Department of Biochemistry, Chacha Nehru Bal Chikitsalya Hospital, Associated to Maulana Azad Medical College, Geeta Colony, New Delhi, 110031 India ;.Department of Pediatrics, Chacha Nehru Bal Chikitsalya Hospital, Associated to Maulana Azad Medical College, Geeta Colony, New Delhi, 110031 India |
| Abstract: | Extensive data from animal and human studies indicate a role of vitamin D in erythropoiesis. Iron and vitamin D deficiencies are implicated with adverse health effects in children even if they are asymptomatic. The potential relationship between the two remains poorly understood. A cross-sectional study was performed in the period from 1st May 2012 through 30th April 2013 and subjects were classified into vitamin D deficiency (VDD), vitamin D insufficiency (VDI) and vitamin D sufficiency (VDS) groups according to their 25(OH) D levels. A total of 263 children were included in the analysis. Anaemia was present in 66 % of 25(OH) D deficient subjects compared with 35 % in vitamin D sufficient individuals (p < 0.0001). The association of breast feeding and development of VDD was also significant (p < 0.05). Serum levels of 25(OH) D were found lower in female sex and if the analysis was performed in the winter/spring season. Physicians should therefore assess vitamin D levels in all anaemic children and ensure adequate supplementation to prevent deficiencies. |
| Keywords: | Vitamin D deficiency Iron deficiency anaemia Supplementation Children Season Breast feeding |