Mitochondrial dysfunction at the early stage of cisplatin-induced acute renal failure in rats |
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| Authors: | Xie Li-ping C Skrezek H Wand F Reibe |
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| Institution: | (1) Dept. of Urology, First Affiliated Hospital, College of Medicine, Zhejiang University, 310003 Hangzhou, China;(2) Christian-Albrechts University of Kiel, 24105 Kiel, Germany |
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| Abstract: | The present study was undertaken to clarify the pathogenesis of cisplatin-induced acute renal failure at the early stage.
Male Sprague-Dawley rats were given an intravenous administration of 10 mg/kg cisplatin. 0.9% saline was infused into them
at a rate of 2 ml/h for 3 h, starting with a 2-ml bolus injection before cisplatin administration. 3 h following cisplatin
administration, no evident morphological abnormalities were found by both light and electron microscopy; there were also no
significant changes in GFR. Thirty min after cisplatin injection, urine sodium and potassium excretion increased by 56% and
260% those of the control animals, respectively. Apparent renal mitochondrial respiration dysfunction was observed in cisplatintreated
rats 3 h later; the state 4 respiration increased by 100% and state 3 respiration, respiratory control ratio and carbonyl
cyanide p-trifluoromethoxyphenyl hydrazone-uncoupled respiration decreased by 46%, 74% and 47% of the controls, respectively.
The present data suggest that mitochondrial dysfunction may be a very early event in cisplatin-induced acute renal failure
in rats. |
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| Keywords: | acute renal failure cisplatin pathogenesis kidney tubule mitochondria |
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