| Lovastatin production by Aspergillus terreus in solid-state fermentation |
| |
| 作者姓名： | WEI Pei-lian XU Zhi-nan CEN Pei-lin |
| |
| 作者单位： | [1]Institute of Biochemical Engineering, Department of Chemical Engineering ＆ Bioengineering, Zhejiang University, Hangzhou 310027, China [2]Department of Biochemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China |
| |
| 基金项目： | Project （No-20061475） supported by Education Department of Zhejiang Province, China The authors would like to thank Miss LI Ju-qing in Zhejiang University of Science and Technology for assistance in HPLC assay. |
| |
| 摘 要： | Lovastatin production by Aspergillus terreus ATCC 20542 in solid-state fermentation (SSF) was studied. Various substrates were used to evaluate the ability of A. terreus to produce lovastatin. The results showed that either rice or wheat bran was suitable substrate for lovastatin production in SSF. The maximum yield of lovastatin (2.9 mg/g dry substrate) using rice as substrate was achieved after incubating for 11 d at the following optimized process parameters: 50%～60% initial moisture content,pH 5.5,incubation temperature 28 °C.
|
| 关 键 词： | 固态发酵 曲霉菌 洛伐他汀 药物生产 |
| 收稿时间： | 8 March 2006 |
| 修稿时间： | 2006-03-082006-08-23 |
Lovastatin production by <Emphasis Type="Italic">Aspergillus terreus</Emphasis> in solid-state fermentation |
| |
| WEI Pei-lian XU Zhi-nan CEN Pei-lin.Lovastatin production by Aspergillus terreus in solid-state fermentation[J].Journal of Zhejiang University Science,2007,8(9):1521-1526. |
| |
| Authors: | Wei Pei-lian Xu Zhi-nan Cen Pei-lin |
| |
| Institution: | (1) Institute of Biochemical Engineering, Department of Chemical Engineering & Bioengineering, Zhejiang University, Hangzhou, 310027, China;(2) Department of Biochemical Engineering, Zhejiang University of Science and Technology, Hangzhou, 310023, China |
| |
| Abstract: | Lovastatin production by Aspergillus terreus ATCC 20542 in solid-state fermentation (SSF) was studied. Various substrates were used to evaluate the ability of A. terreus to produce lovastatin. The results showed that either rice or wheat bran was suitable substrate for lovastatin production
in SSF. The maximum yield of lovastatin (2.9 mg/g dry substrate) using rice as substrate was achieved after incubating for
11 d at the following optimized process parameters: 50%∼60% initial moisture content, pH 5.5, incubation temperature 28 °C.
Project (No. 20061475) supported by Education Department of Zhejiang Province, China |
| |
| Keywords: | Solid-state fermentation (SSF) Rice Lovastatin Aspergillus terreus |
| 本文献已被 维普 万方数据 SpringerLink 等数据库收录！ |
