| 妊娠期糖尿病相关炎性因子的研究进展 |
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| 引用本文： | 何可人,单莉莉,刘芳,王珊.妊娠期糖尿病相关炎性因子的研究进展[J].深圳职业技术学院学报,2021(1). |
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| 作者姓名： | 何可人 单莉莉 刘芳 王珊 |
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| 作者单位： | 深圳职业技术学院医学技术及护理学院;深圳市妇幼保健院 |
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| 基金项目： | 2018年度深圳职业技术学院青年创新科研资助项目(601822K31020). |
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| 摘 要： | 目前妊娠期糖尿病的发病机制尚不完全清楚,随着研究的进展,免疫炎症假说日益受到学者的重视.妊娠期糖尿病的发病与病人体内的促炎/抗炎细胞因子平衡失常有关,该平衡倾向于促炎细胞因子的分泌,而抗炎细胞因子在疾病的发生、发展中可能发挥保护作用,文章综述了促炎细胞因子(TNF-6、IL-6、IFN-γ、IL-2、IL-17、IL-1β)和抗炎细胞因子(IL-10、IL-37、IL-4)在妊娠期糖尿病发生、发展中的作用,以及它们在临床筛查和诊断中的应用,以期为妊娠期糖尿病的预测和防治提供参考.
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| 关 键 词： | 妊娠期糖尿病 炎性因子 胰岛素抵抗 发病机制 |
Research Progress of Inflammatory Factors Related to Gestational Diabetes Mellitus |
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| HE keren,SHAN Lili,LIU Fang,WANG Shan.Research Progress of Inflammatory Factors Related to Gestational Diabetes Mellitus[J].Journal of Shenzhen Polytechnic,2021(1). |
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| Authors: | HE keren SHAN Lili LIU Fang WANG Shan |
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| Institution: | (I.School of Medical Technology and Nursing,Shenzhen Polytechnic,Shenzhen,Guangdong 518055,China;Shenzhen Maternal and Child Health Hospital,Shenzhen,Guangdong 518028,China) |
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| Abstract: | The pathogenesis of gestational diabetes mellitus(GDM)is not fully known.With the development of research,scholars have paid increasing attention to the immune inflammation hypothesis.GDM is caused by the loss of balance between pro-and anti-inflammatory cytokines.This balance tends to favor the secretion of pro-inflammatory cytokines.Anti-Inflammatory cytokines may prevent the development of GDM.This article reviews the role of pro inflammatory cytokines(TNF-6,IL-6,IFN-γ,IL-2,IL-17,IL-1β)and anti-inflammatory cytokines(IL-10,IL-37,IL-4)in the development and progression of GDM,and further discusses their application in clinical screening and diagnosis in order to provide some new thinking for the prediction and prevention of GDM. |
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| Keywords: | gestational diabetes mellitus inflammatory factor insulin resistance pathogenesis |
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