| 苦参碱抗肿瘤作用机制研究进展 |
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| 引用本文： | 秦昆明,方前波,蔡皓,蔡宝昌.苦参碱抗肿瘤作用机制研究进展[J].深圳职业技术学院学报,2009,8(3):61-66. |
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| 作者姓名： | 秦昆明 方前波 蔡皓 蔡宝昌 |
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| 作者单位： | 南京中医药大学江苏省中药炮制重点实验室,江苏南京,210029 |
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| 基金项目： | 国家药典委员会资助项目 |
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| 摘 要： | 苦参碱的抗肿瘤机制较为广泛，包括抑制端粒酶活性、抑制肿瘤细胞增殖、抑制肿瘤细胞转移和诱导肿瘤细胞凋亡等．近年来，对苦参碱抗肿瘤机制的研究又有了新进展，相关研究已经深入到分子和基因水平，本文对近年来苦参碱抗肿瘤作用机制研究方面取得的最新进展进行了综述，并对苦参碱抗肿瘤作用的研究方向进行了展望．
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| 关 键 词： | 苦参碱 抗肿瘤作用 机制 |
Summary of Research on Anticancer Mechanism of Constituent Matrine |
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| QIN Kunming,FANG Qianbo,CAI Hao,CAI Baochang.Summary of Research on Anticancer Mechanism of Constituent Matrine[J].Journal of Shenzhen Polytechnic,2009,8(3):61-66. |
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| Authors: | QIN Kunming FANG Qianbo CAI Hao CAI Baochang |
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| Institution: | ( Jiangsu Key Laboratory of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210029, China ) |
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| Abstract: | Matrine is an effective anticancer compound in traditional Chinese medicine Sophoraflavescens Air, which is endowed with ant/cancer mechanisms, including inhibiting activity of telomerase, and tumor proliferation, preventing invasion of tumor cells and inducing apoptosis of tumor cells. In recent years, new progress in the research of anticancer mechanisms of matrine has been made, with some reaching molecular and genetic level. This paper presents a summary of anticancer mechanism of this compound in recent years, and a research trend of anticancer effect of matrine. |
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| Keywords: | matrine anticancer effect mechanism |
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