Plasticity of human menstrual blood stem cells derived from the endometrium |
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| Authors: | Lin Jian Xiang Dennis Zhang Jin-long Allickson Julie Xiang Charlie |
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| Institution: | (1) Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Trauma Center of Postgraduate Medical College, General Hospital of PLA, 28 Fu Xing Road, Beijing, 100853, P. R. China;(2) Shantou University Medical College, GuangDong Province, Shantou, 515063, P. R. China |
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| Abstract: | Stem cells can be obtained from women’s menstrual blood derived from the endometrium. The cells display stem cell markers
such as Oct-4, SSEA-4, Nanog, and c-kit (CD117), and have the potent ability to differentiate into various cell types, including
the heart, nerve, bone, cartilage, and fat. There has been no evidence of teratoma, ectopic formation, or any immune response
after transplantation into an animal model. These cells quickly regenerate after menstruation and secrete many growth factors
to display recurrent angiogenesis. The plasticity and safety of the acquired cells have been demonstrated in many studies.
Menstrual blood-derived stem cells (MenSCs) provide an alternative source of adult stem cells for research and application
in regenerative medicine. Here we summarize the multipotent properties and the plasticities of MenSCs and other endometrial
stem cells from recent studies conducted both in vitro and in vivo. |
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