| Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension |
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| 作者姓名： | YU Min WANG Xing-xiang ZHANG Fu-rong SHANG Yun-peng DU Yu-xi CHEN Hong-juan CHEN Jun-zhu |
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| 作者单位： | YU Min1，WANG Xing-xiang 1，ZHANG Fu-rong1，SHANG Yun-peng1，DU Yu-xi2，CHEN Hong-juan1，CHEN Jun-zhu 1(1Department of Cardiovascular Disease，the First Affiliated Hospital，School of Medicine，Zhejiang University，Hangzhou 310003，China)(2Department of Cardiovascular Disease，Taizhou Hospital，Taizhou 317000，China) |
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| 基金项目： | Project (No. A-007) supported by the Key Medicine Foundation of Zhejiang Province, China |
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| 摘 要： | Idiopathic pulmonary arterial hypertension(IPAH) is a rare disease of unknown etiology.The exact pathogenesis of pulmonary arterial hypertension is still not well known.In the past decades,many protein molecules have been found to be in-volved in the development of IPAH.With proteomic techniques,profiling of human plasma proteome becomes more feasible in searching for disease-related markers.In present study,we showed the protein expression profiles of the serum of IPAH and healthy controls after depleting a few high-abundant proteins in serum.Thirteen spots had changed significantly in IPAH com-pared with healthy controls and were identified by LC-MS/MS.Alpha-1-antitrypsin and vitronectin were down-regulated in IPAH and may be valuable candidates for further explorations of their roles in the development of IPAH.
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| 收稿时间： | 19 January 2007 |
Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension |
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| YU Min,WANG Xing-xiang ,ZHANG Fu-rong,SHANG Yun-peng,DU Yu-xi,CHEN Hong-juan,CHEN Jun-zhu .Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension[J].Journal of Zhejiang University Science,2007,8(4):221-227. |
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| Authors: | YU Min WANG Xing-xiang ZHANG Fu-rong SHANG Yun-peng DU Yu-xi CHEN Hong-juan CHEN Jun-zhu |
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| Institution: | (1) Department of Cardiovascular Disease, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China;(2) Department of Cardiovascular Disease, Taizhou Hospital, Taizhou, 317000, China |
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| Abstract: | Idiopathic pulmonary arterial hypertension(IPAH) is a rare disease of unknown etiology.The exact pathogenesis of pulmonary arterial hypertension is still not well known.In the past decades,many protein molecules have been found to be in-volved in the development of IPAH.With proteomic techniques,profiling of human plasma proteome becomes more feasible in searching for disease-related markers.In present study,we showed the protein expression profiles of the serum of IPAH and healthy controls after depleting a few high-abundant proteins in serum.Thirteen spots had changed significantly in IPAH com-pared with healthy controls and were identified by LC-MS/MS.Alpha-1-antitrypsin and vitronectin were down-regulated in IPAH and may be valuable candidates for further explorations of their roles in the development of IPAH. |
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| Keywords: | Idiopathic pulmonary arterial hypertension Two-dimensional gel electrophoresis LC-MS/MS |
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