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| MicroRNA在肿瘤免疫中的作用：对肿瘤相关巨噬细胞的功能调控（英文） | |
| 作者姓名： | Chong CHEN Jia-ming LIU Yun-ping LUO |
| 作者单位： | Department of Immunology;Collaborative Innovation Center for Biotherapy |
| 基金项目： | Project supported by the National Natural Science Foundation of China(Nos.81972795 and 1672914) |
| 摘 要： | 肿瘤相关巨噬细胞(TAM)是肿瘤微环境中比例最高的免疫细胞,对肿瘤的发生和发展起着重要的作用。在肿瘤的进展过程中,microRNA可以通过转录后调控的方式作用于多种靶点与信号通路来影响TAM的表型。本文主要讨论了microRNA对巨噬细胞分化、功能性极化和细胞间信息交流的调控作用。首先,microRNA参与了从髓样细胞向成熟巨噬细胞的分化过程,这一过程直接影响了肿瘤微环境中肿瘤细胞对巨噬细胞的招募。其次,microRNA参与了TAM的功能极化,使之表现为促癌或抑癌表型,影响了肿瘤的生长和转移。第三,肿瘤细胞与巨噬细胞间的相互作用对肿瘤微环境的形成和肿瘤的进展而言是必要的,microRNA可以通过胞外颗粒的形式作为交流的媒介。此外,本文还讨论了巨噬细胞相关microRNA作为肿瘤诊断和预后标志物的潜在价值,以及基于巨噬细胞相关microRNA的肿瘤治疗新策略的应用前景。 |
| 关 键 词： | MICRORNA 肿瘤微环境 肿瘤相关巨噬细胞 功能性极化 |
MicroRNAs in tumor immunity: functional regulation in tumor-associated macrophages |
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| Chong CHEN,Jia-ming LIU,Yun-ping LUO.MicroRNAs in tumor immunity: functional regulation in tumor-associated macrophages[J].Journal of Zhejiang University Science,2020,21(1):12-28. | |
| Authors: | Chen Chong Liu Jia-ming Luo Yun-ping |
| Institution: | 1.Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences; School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China ;2.Collaborative Innovation Center for Biotherapy, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences; School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China ; |
| Abstract: | |
| Keywords: | MicroRNA Tumor microenvironment Tumor-associated macrophage Functional polarization |
| 本文献已被 CNKI 维普 SpringerLink 等数据库收录！ | |