| Polymorphisms in the genes for coagulation factor II,V,VII in patients undergoing coronary angiography |
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| 作者姓名： | 徐耕 金国栋 傅国胜 马骥 单江 王建安 |
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| 作者单位： | The Second Affiliated Hospital，College of Medicine，Zhejiang University，The Second Affiliated Hospital，College of Medicine，Zhejiang University，The Second Affiliated Hospital，College of Medicine，Zhejiang University，The Second Affiliated Hospital，College of Medicine，Zhejiang University，The Second Affiliated Hospital，College of Medicine，Zhejiang University，Sir Run Run Shaw Hospital，College of Medicine，Medicine，Zhejiang University Hangzhou 310009，China，Hangzhou 310009，China，Hangzhou 310009，China，Hangzhou 310009，China，Hangzhou 310009，China，Hangzhou 310009，China |
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| 基金项目： | Project(No .0 2 110 3 166)supportedbyagrantfromtheKeyProjectofScienceandTechnologyCommissionofZhejiangProvince，China |
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| 摘 要： | INTRODUCTIONCoronaryarterydisease (CAD)continuestobethemajorcauseofmorbidityandmortalityinourcountry .TheactivityofbloodcoagulationfactorshasbeenshowntobeanimportantriskindicatorforCAD .However,circulatinglevelsofcoagulationfactorsmaynotaccuratelyreflectt…
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Polymorphisms in the genes for coagulation factor II,V,VII in patients undergoing coronary angiography |
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| XU Geng,JIN Guo dong,FU Guo sheng ,MA Ji,SHAN Jiang,WANG Jian anWT.,.BZ.Polymorphisms in the genes for coagulation factor II,V,VII in patients undergoing coronary angiography[J].Journal of Zhejiang University Science,2003(3). |
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| Authors: | XU Geng JIN Guo dong FU Guo sheng MA Ji SHAN Jiang WANG Jian an[WT BZ] |
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| Institution: | XU Geng,JIN Guo dong,FU Guo sheng 1,MA Ji,SHAN Jiang,WANG Jian an[WT9.,10.BZ] |
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| Abstract: | Objective: To determine whether polymorphisms in the genes for coagulation factor II,V, VII could predispose an individual to increase risk for coronary artery disease (CAD) and/or myocardial infarction (MI) in Chinese. Methods: We screened coagulation factor II(G20210A),V(G1691A),VII (R353Q and HVR4) genotype in 374 patients undergoing coronary angiography by polymerase chain reaction and restriction fragment length polymorphism (PCR RFLP) assay. Results: The R353Q and HVR4 genotype of the factor VII distribution was in accordance with Hardy Weinberg equilibrium. The frequencies of FVII genotype or allele did not show statistically significant differences between CAD group and controls or between male and female. The frequencies of the Q allele and (RQ QQ) genotype were significantly higher among the CAD patients without myocardial infarction (MI) history than among those with MI history ( P <0.05). However, HVR4 polymorphism was not significantly different within groups. We only find one normal control of factorII(G20210A) mutation. No coagulation factor V(G1691A) mutation was found in the CAD patients and controls. Conclusion: The factor II(G20210A),V(G1691A) mutation is absent and may not be a major genetic factor for CAD and/or MI; the Q allele of the R353Q polymorphism of the factor VII gene may be a protective genetic factor against myocardial infarction in Chinese. |
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| Keywords: | Coagulation factor Polymorphism Coronary angiography Myocardial infarction |
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