A probiotic treatment containing Lactobacillus, Bifidobacterium and Enterococcus improves IBS symptoms in an open label trial |
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| Authors: | Yu-jing Fan Shu-jie Chen Ying-cong Yu Jian-min Si Bin Liu |
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| Institution: | (1) Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China;(2) Department of Gastroenterology, Tongren Hospital, Capital Medical University, Beijing, 100730, China |
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| Abstract: | Objective: To evaluate the efficacy and safety of live combined Bifidobacterium, Lactobacillus and Enterococcus capsules in
treatment of irritable bowel syndrome. Methods: Eighty-five patients male 32, female 53; age (45.31±11.72) years] were given
live combined Bifidobacterium, Lactobacillus and Enterococcus capsules 1260 mg/d t.i.d.×4 weeks. Syndrome scales were used
to evaluate the efficacy in gastrointestinal syndrome. Fecal flora was also measured before and after the treatment. Six bacteria
were cultured and the colony forming units were counted in stool. SPSS was used for data analysis. Results: Seventy-four patients
finished the follow-up. No side-effect was found. For treatment of irritable bowel syndrome, the effective rate of live combined
Bifidobacterium, Lactobacillus and Enterococcus capsules was 56.8% in the second week, 74.3% in the fourth week and 73.0%
in the sixth week. Single symptom was improved, especially in abdominal pain and stool character. The probiotica containing
live combined Bifidobacterium, Lactobacillus and Enterococcus could increase bifidobacterium count (P<0.01) and lactobacillus count (P<0.05); decrease bacteroides count (P<0.05) and enterococci count (P<0.01); No obvious changes were observed in clostridium difficile colonitis and enterobacteriaceae (P>0.05). Conclusion: The result of the study indicated that the administration of live combined Bifidobacterium, Lactobacillus
and Enterococcus improved the symptom of irritable bowel syndrome and that there was a gradual increase of this effect. Thereafter
conditions remained stable for 2 weeks. That improvement may be associated with alterations in gastrointestinal flora.
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| Keywords: | Irritable bowel syndrome (IBS) Intestinal flora Probiotic agents |
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