| Dendritic cell therapy with improved outcome in glioma multiforme-a case report |
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| 作者姓名： | Khan JA Yaqin S |
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| 作者单位： | Microbiology Research Lab, C-38/Sector 20, Noida （U.P.）, 201301, India |
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| 基金项目： | Project partly supported by the paticnt＇s cooperation and by Amim Cancer Trust, India |
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| 摘 要： | Malignant gliomas are the most devastating tumors in clinical practice and nave poorest survival, Immunological treatment of such patients may likely increase the survival and quality of life. Dendritic cells （DCs）, most potent antigen presenting cells in combination with oral chemotherapeutic agents may be tried for patients giving consent to such treatment. We have successfully combined the two therapies in an adult male patient who was on downhill course after being operated on once with post operation chemotherapy and radiotherapy for glioma in the left parietal area. He received five dendritic cell therapy vaccines in combination with oral chemotherapy and responded dramatically having near normal quality of life for an additional five months with this regime, increasing the survival after operation to 11 months. This therapy is continuing with radiological betterment of the lesion. The DCs are matured with antigen extracted from wax embedded tissue at 6th day of culture. We feel that the treatment can be given to more number of patients to establish its efficacy for the dreaded cancer glioblastoma multiforme.
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| 关 键 词： | 多形性神经胶质瘤 治疗 树突状细胞 免疫疗法 |
| 收稿时间： | 2005-11-18 |
| 修稿时间： | 2005-12-13 |
Dendritic cell therapy with improved outcome in glioma multiforme—A case report |
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| Khan JA,Yaqin S.Dendritic cell therapy with improved outcome in glioma multiforme-a case report[J].Journal of Zhejiang University Science,2006,7(2):114-117. |
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| Authors: | Jamal A Khan Sharmin Yaqin |
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| Institution: | (1) Microbiology Research Lab, C-38/Sector 20, Noida (U.P.), 201301, India |
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| Abstract: | Malignant gliomas are the most devastating tumors in clinical practice and have poorest survival. Immunological treatment
of such patients may likely increase the survival and quality of life. Dendritic cells (DCs), most potent antigen presenting
cells in combination with oral chemotherapeutic agents may be tried for patients giving consent to such treatment. We have
successfully combined the two therapies in an adult male patient who was on downhill course after being operated on once with
post operation chemotherapy and radiotherapy for glioma in the left parietal area. He received five dendritic cell therapy
vaccines in combination with oral chemotherapy and responded dramatically having near normal quality of life for an additional
five months with this regime, increasing the survival after operation to 11 months. This therapy is continuing with radiological
betterment of the lesion. The DCs are matured with antigen extracted from wax embedded tissue at 6th day of culture. We feel
that the treatment can be given to more number of patients to establish its efficacy for the dreaded cancer glioblastoma multiforme.
Project partly supported by the patient’s cooperation and by Amim Cancer Trust, India |
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| Keywords: | Dendritic cells Glioma Immunetherapy |
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