| Study progress on mechanism of severe acute pancreatitis complicated with hepatic injury |
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| 作者姓名： | ZHANG Xi-ping WANG Lei ZHANG Jie |
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| 作者单位： | ZHANG Xi-ping1，WANG Lei2，ZHANG Jie2(1Department of General Surgery，Hangzhou First People’s Hospital，Hangzhou 310006，China)(2Zhejiang University of Traditional Chinese Medicine，Hangzhou 310053，China) |
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| 基金项目： | Project supported by the Administration of Traditional Chinese Medicine of Zhejiang Province (Nos. 2003C130 and 2004C142)，the Medical Science and Technology of Health Department of Zhejiang Province (No. 2003B134)，the Technology and Development of Technological Bureau of Hangzhou (No. 2003123B19), China |
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| 摘 要： | Study on the action mechanism of inflammatory mediators generated by the severe acute pancreatitis(SAP) in mul-tiple organ injury is a hotspot in the surgical field.In clinical practice,the main complicated organ dysfunctions are shock,res-piratory failure,renal failure,encephalopathy,with the rate of hepatic diseases being closely next to them.The hepatic injury caused by SAP cannot only aggravate the state of pancreatitis,but also develop into hepatic failure and cause patient death.Its complicated pathogenic mechanism is an obstacle in clinical treatment.Among many pathogenic factors,the changes of vasoac-tive substances,participation of inflammatory mediators as well as OFR(oxygen free radical),endotoxin,etc.may play important roles in its progression.
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| 关 键 词： | Severe acute pancreatitis Hepatic injury Inflammatory mediators Cytokines Endotoxin Nuclear factor-κB |
| 收稿时间： | 13 June 2006 |
| 修稿时间： | 22 December 2006 |
Study progress on mechanism of severe acute pancreatitis complicated with hepatic injury |
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| ZHANG Xi-ping,WANG Lei,ZHANG Jie.Study progress on mechanism of severe acute pancreatitis complicated with hepatic injury[J].Journal of Zhejiang University Science,2007,8(4):228-236. |
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| Authors: | ZHANG Xi-ping WANG Lei ZHANG Jie |
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| Institution: | (1) Department of General Surgery, Hangzhou First People’s Hospital, Hangzhou, 310006, China;(2) Zhejiang University of Traditional Chinese Medicine, Hangzhou, 310053, China |
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| Abstract: | Study on the action mechanism of inflammatory mediators generated by the severe acute pancreatitis(SAP) in mul-tiple organ injury is a hotspot in the surgical field.In clinical practice,the main complicated organ dysfunctions are shock,res-piratory failure,renal failure,encephalopathy,with the rate of hepatic diseases being closely next to them.The hepatic injury caused by SAP cannot only aggravate the state of pancreatitis,but also develop into hepatic failure and cause patient death.Its complicated pathogenic mechanism is an obstacle in clinical treatment.Among many pathogenic factors,the changes of vasoac-tive substances,participation of inflammatory mediators as well as OFR(oxygen free radical),endotoxin,etc.may play important roles in its progression. |
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| Keywords: | Severe acute pancreatitis Hepatic injury Inflammatory mediators Cytokines Endotoxin Nuclear factor-κ B |
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