| 溃疡性结肠炎免疫学发病机理探讨及血清自身抗体检测 |
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| 引用本文： | 胡野,单小云.溃疡性结肠炎免疫学发病机理探讨及血清自身抗体检测[J].金华职业技术学院学报,2001,1(4):51-54. |
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| 作者姓名： | 胡野 单小云 |
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| 作者单位： | 1. 金华市职业技术学院医学院院长,副教授,321000,金华市
2. 金华市中心医院,主管检验师,321000,金华市 |
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| 摘 要： | 溃疡性结肠炎(ulcerative colitis，UC)是一种原因不明主要发生在结肠粘膜层的炎症性病变，以溃疡糜烂为主。其病因及发病机制目前尚无定论，但倾向性意见是UC与自身免疫紊乱有关，所涉及到的自身抗体主要归纳为两类，一类是抗结肠抗体(ACA)，另一类是抗人中性粒细胞胞质抗体(ANCA)。本文就溃疡性结肠炎免疫学发病机理及血清自身抗体检测的临床应用加以阐述，以便为UC病因学和诊断学的研究提供客观依据。
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| 关 键 词： | 溃疡性结肠炎 免疫学 抗结肠抗体 血清学 诊断 病因 |
| 修稿时间： | 2001年9月14日 |
Immunologic Mechanism of Idiopathic Ulcerative Colitis and the Clinical Application of Detection of Auto-antibodies in Sera |
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| Hu,Ye,Shan Xiaoyun.Immunologic Mechanism of Idiopathic Ulcerative Colitis and the Clinical Application of Detection of Auto-antibodies in Sera[J].Journal of Jinhua College of Profession and Technology,2001,1(4):51-54. |
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| Authors: | Hu Ye Shan Xiaoyun |
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| Abstract: | The major complaints with idiopathic ulcerative colitis(UC)are pathologic changes of inflam-mation in colon mucosa,ulcerating lesion predominantly and unexplained.Etiology and mechanism of UC are not unequivocally established recently,but the disease bears relation to the disturbance of auto-immunity.The auto-antibodies concerned are primarily classified into anti-colon antibodies(ACA)and anti-neutrophil cytoplasmic antibodies(ANCA).This paper focus on immunologic mech-anism of idiopathic ulcerative colitis and the application of detection of auto-antibodies in sera with a view to provide objective evidence of etiology and diagnosis. |
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| Keywords: | Idiopathic ulcerative colitis(UC)Anti-colon antibodies ACA Anti-neutrophil cytoplasmic antibodies(ANCA)The clinical application |
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