| 金樱子多糖对药物性肝损伤小鼠血脂代谢的影响 |
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| 引用本文： | 皮朝琼,真义才,蔡珊兰,皮建辉.金樱子多糖对药物性肝损伤小鼠血脂代谢的影响[J].怀化学院学报,2011,30(11):36-38. |
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| 作者姓名： | 皮朝琼 真义才 蔡珊兰 皮建辉 |
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| 作者单位： | 怀化学院生命科学系,湖南怀化,418008 |
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| 基金项目： | 2010年湖南省大学生研究性学习与创新性项目立项资助课题 |
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| 摘 要： | 为探讨金樱子多糖（RP）对药物性肝损伤小鼠血脂代谢的影响，采用KM小鼠为研究动物，将小鼠平均分为5组（高、中、低剂量组、正常组、模型组），RP连续灌喂5周．其中第5周的星期一、三、五、日在正常灌胃后2h，除正常组外，其余4组均按5mL／kg腹腔注射0．5％CCl4的花生油溶液，并于末次注射CCl4后18h摘眼球取血，测...
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| 关 键 词： | 金樱子多糖 血脂代谢 肝损伤小鼠 |
The Effect of the Polysaccharides from Rosa Lacvigata on Blood Lipid Metabolism in Mice with Damaged Liver by Drug |
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| Abstract: | In order to study the effects of Rosa Lacvigata polysaccharide （RP） on lipid levels of drug- induced liver injury mice. We treated KM mice as study models, and the mouse were divided into 5 groups （high - dosage group, medium - dosage group, low - dosage group, normal group and model group） and feed them with Rosa Lacvigata polysaccharide for 5 weeks. On Monday, Wednesday, Friday and Sunday in the last week, the other four groups were applied 0.5 % CCl4 solution in peanut oil by intraperitoneal injection basis 5 mL/kg body weight except the normal group, respectively. And 18 hours after the last injection, we killed the mouse and took blood in order to determine the content of triglyceride （TG）, total cholesterol （TC）, LDI, - cholesterol （LDL- C） and HDL- cholesterol （HDL- C） in serum. The results showed that Rosa Lacvigata polysaccharide can lower TC, TG, LDL - C and raise HDL - C in serum. It suggested that RP played the role of a good correction on drug - induced liver injury in mice with lipid metabolism. |
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| Keywords: | Rosa Lacvigata polysaccharides blood lipid metabolism mice with damaged liver |
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