| 荧光光谱法研究甲磺酸酚妥拉明与血红蛋白的结合作用 |
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| 引用本文： | 荣玉芝,赵波,陈昌云.荧光光谱法研究甲磺酸酚妥拉明与血红蛋白的结合作用[J].南京晓庄学院学报,2007,23(3):33-36. |
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| 作者姓名： | 荣玉芝 赵波 陈昌云 |
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| 作者单位： | 1. 南京师范大学,化学与环境科学学院,江苏,南京,210097
2. 南京晓庄学院,化学系,江苏,南京,210017 |
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| 基金项目： | 江苏省教育厅自然科学基金(05KJB430058)，江苏省科技厅自然科学基金(BK2005118)，国家自然科学基金(20471030,30570323)资助项目 |
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| 摘 要： | 药物摄入人体之后,与血液中的血红蛋白结合,从而使血红蛋白的结构和功能发生改变.因此,研究甲磺酸酚妥拉明与血红蛋白的相互作用机理有助于阐明药物在生物体内的运输和代谢机制、药物的毒理机制,以及了解蛋白质的结构与功能关系都具有非常重要的意义.本文用荧光光谱技术研究了甲磺酸酚妥拉明与牛血红蛋白的相互作用机理,确定了相互作用的结合常数及结合位点数.
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| 关 键 词： | 甲磺酸酚妥拉明 血红蛋白 作用机理 荧光光谱 |
| 文章编号： | 1009-7902（2007）03-0033-04 |
| 修稿时间： | 2007-02-05 |
Study on the Interaction Between Phentolamine Mesylate and Hemoglobin |
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| RONG Yu-zhi,ZHAO Bo,CHEN Chang-yun.Study on the Interaction Between Phentolamine Mesylate and Hemoglobin[J].Journal of Nanjing Xiaozhuang College,2007,23(3):33-36. |
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| Authors: | RONG Yu-zhi ZHAO Bo CHEN Chang-yun |
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| Institution: | 1. College of Chemistry and Environmental Science, Nanjing Normal University, Nanjing 210097, Jiangsu; 2. Department of Chemistry, Nanjing Xiaozhuang University, Nanjing 210017, Jiangsu |
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| Abstract: | The drugs will bind with the hemoglobin in the blood, changing the structure and function of hemoglobin,after it comes into the human's body.So understanding the interaction mechanism between phentolamine mesylate and hemoglobin has an important significance in illustrating transport and metabolize mechanism of drugs into the organism,toxicity and giving the relationship between the structure and the function of protein.In this paper,the interaction mechanism between phentolamine mesylate and bovine hemoglobin is investigated by using fluorescence spectroscopy technology,the binding constant and numbers of binding sites are confirmed. |
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| Keywords: | phentolamine mesylate hemoglobin interaction mechanism fluorescence spectra |
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