| 奥扎格雷中DMF残留量的测定 |
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| 引用本文： | 陈改敏,闫学斌,李雯,李惠举,姬小明.奥扎格雷中DMF残留量的测定[J].南阳师范学院学报,2006,5(6):55-57. |
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| 作者姓名： | 陈改敏 闫学斌 李雯 李惠举 姬小明 |
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| 作者单位： | 1. 郑州大学,化学系,新药研究开发中心,河南,郑州,450052
2. 郑州大学,化工系,河南,郑州,450002 |
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| 摘 要： | 建立了直接进样毛细管气相色谱法测定奥扎格雷中DMF残留量的方法。色谱柱为HP-FFAP石英毛细管柱,采用程序升温,载气为氮气,检测器为FID,以DMSO为溶剂。在上述色谱条件下,DMF的线性范围为1.76~15.84 mg/L,平均加样回收率为95.14%。此方法可用于测定原料药中DMF的残留量。
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| 关 键 词： | 毛细管气相色谱法 奥扎格雷 残留溶剂 DMF |
| 文章编号： | 1671-6132（2006）06-0055-02 |
| 收稿时间： | 2006-04-17 |
| 修稿时间： | 2006年4月17日 |
On determination of residual amount of DMF in ozagrel by capillary GC |
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| CHEN Gai-min,YAN Xue-bin,LI Wen,LI Hui-ju,JI Xiao-ming.On determination of residual amount of DMF in ozagrel by capillary GC[J].Journal of Nanyang Teachers College,2006,5(6):55-57. |
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| Authors: | CHEN Gai-min YAN Xue-bin LI Wen LI Hui-ju JI Xiao-ming |
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| Abstract: | A capillary gas chromatographic method with directly sampling was established to determination the residual amount of DMF in ozagrel. The analytical column was HP - FFAP capillary quartz column. The column temperature was programmed. The carrier gas was nitrogen. The detector was FID. DMSO was selected as solvent. The linear range for DMF was 1.76- 15.84 mg/L. The average recovery of them was 95.14%. In conclusion, the method was simple, rapidly, special, precision and it could be used for the determination of the residual amount of DMF in drug substances. |
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| Keywords: | capillary GC ozagrel residual solvent DMF |
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